Single-Benzene-Based Clickable Fluorophores for In Vitro and In Vivo Bioimaging

Mohanrao, R, Pinto, CS, Suchenko, A, Clarkson, GJ, Wills, M, Roesner, S ORCID: 0000-0003-2143-4708, Shipman, M and Balasubramanian, MK (2025) Single-Benzene-Based Clickable Fluorophores for In Vitro and In Vivo Bioimaging. Chemistryselect, 10 (9). e202405738-e202405738. ISSN 2365-6549

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Abstract

A series of miniaturized, clickable single-benzene-based fluorophores derived from tetrafluoroterephthalonitrile is reported. Fluorophores based on a tetrahydroquinoxaline skeleton exhibited improved photophysical properties due to enhanced electron delocalization between donor and acceptor groups compared to those with a dihydro[1,4]thiazine skeleton. These easily synthesized clickable fluorophores were successfully applied in both in vitro and in vivo bioimaging following protein conjugation.

Item Type:	Article
Uncontrolled Keywords:	Bioconjugates; Bioimaging; Chromophores; Fluorescent probes; Single-benzene fluorophores; 34 Chemical Sciences; 03 Chemical Sciences; 34 Chemical sciences
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Wiley
Date of acceptance:	20 January 2025
Date of first compliant Open Access:	15 October 2025
Date Deposited:	15 Oct 2025 13:40
Last Modified:	15 Oct 2025 13:45
DOI or ID number:	10.1002/slct.202405738
URI:	https://researchonline.ljmu.ac.uk/id/eprint/27346

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