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Bachar, SC, Nahar, L and Sarker, SD (2016) Synthesis and structure-activity-relationships of indan acid derivatives as analgesic and anti-inflammatory agents. Review Journal of Chemistry, 6 (2). pp. 125-138. ISSN 2079-9799
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Abstract
Indan ring system, also known as indane or benzocyclopentane, is an important chemical feature associated with various biological activities. Among the drugs possessing an indan ring system, 1H-indene-3-acetic acid-5-fluoro-2-methyl-1-[4-(methylsulfinyl)-phenyl]methylene (Sulindac) and 6-chloro-5-cyclohexyl indan-1-carboxylic acid (Clidanac) are well known anti-inflammatory agents, whilst indan-1,3-dione is an anticoagulant. Over the years, several indan derivatives, particularly indan acid derivatives, have been synthesized and their potential analgesic and anti-inflammatory properties have been studied. This review critically appraises various synthetic protocols and structure-activity-relationships of indan acids as analgesic and anti-inflammatory agents with low ulcerogenicity.
| Item Type: | Article |
|---|---|
| Additional Information: | The final publication is available at Springer via http://dx.doi.org/10.1134/S2079978016020011 |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Springer Verlag |
| Date Deposited: | 01 Feb 2016 12:19 |
| Last Modified: | 04 Sep 2021 13:31 |
| DOI or ID number: | 10.1134/S2079978016020011 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/2797 |
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