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Ali, HRH, Saleem, IY and Tawfeek, HM (2016) Insight into inclusion complexation of indomethacin nicotinamide cocrystals. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 84 (3). pp. 179-188. ISSN 1388-3127
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Insight into inclusion complexation of indomethacin nicotinamide cocrystals_uncorrected proof.pdf - Accepted Version Download (1MB) | Preview |
Abstract
The objective of this research was to investigate the feasibility of the interaction between indomethacin-nicotinamide cocrystals with β-cyclodextrin and hydroxypropyl-β-cyclodextrin in the solid-state. The study has emphasized on the possibility of inclusion complex formation and its effect on the dissolution performance of the cocrystals. The solid systems in the molar ratio of 1:1 of the host and guest molecules were prepared by co-grinding and co-evaporation methods and compared with their physical mixtures. Furthermore, the molecular behaviors of the cocrystals in all prepared samples were thoroughly characterized by powder X-ray diffraction, differential scanning calorimetry, Fourier-transform infrared spectroscopy, scanning electron microscopy and in-vitro dissolution performance. The results of these studies indicated that complexes prepared by the co-evaporation method with hydroxypropyl-β-cyclodextrin have shown complete inclusion of the cocrystals into the cyclodextrin cavity and a partial inclusion with β-cyclodextrin. Moreover, a significant (p < 0.05; ANOVA/Tukey) higher in-vitro dissolution was achieved in co-evaporate complex prepared with hydroxypropyl-β-cyclodextrin compared to that prepared with β-cyclodextrin, indomethacin-nicotinamide cocrystals and indomethacin itself.
| Item Type: | Article |
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| Additional Information: | The final publication is available at Springer via http://dx.doi.org/10.1007/s10847-016-0594-3 |
| Uncontrolled Keywords: | 03 Chemical Sciences |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Springer |
| Date Deposited: | 23 Aug 2016 09:05 |
| Last Modified: | 02 Aug 2022 15:33 |
| DOI or ID number: | 10.1007/s10847-016-0594-3 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/2971 |
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