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Cocking, S, Landman, T, Benson, M, Lord, R, Jones, H, Gaze, D, Thijssen, DHJ and George, KP (2016) The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise. Scandinavian Journal of Medicine and Science in Sports. ISSN 1600-0838
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The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise.pdf - Accepted Version Download (657kB) | Preview |
Abstract
Remote ischemic preconditioning (RIPC; repeated short reversible periods of ischemia) protects the heart against subsequent ischemic injury. We explored whether RIPC can attenuate post-exercise changes in cardiac troponin T (cTnT) and cardiac function in healthy individuals. In a randomized, crossover design, 14 participants completed 1-h cycling time trials (TT) on two separate visits; preceded by RIPC (arms/legs, 4 × 5-min 220 mmHg), or SHAM-RIPC (20 mmHg). Venous blood was sampled before and 0-, 1-, and 3-h post-exercise to assess high sensitivity (hs-)cTnT and brain natriuretic peptide (NT-proBNP). Echocardiograms were performed at the same time points to assess left and right ventricular systolic (ejection fraction; EF and right ventricular fractional area change; RVFAC, respectively) and diastolic (early transmitral flow velocities; E) function. Baseline hs-cTnT was not different between RIPC and SHAM. Post-exercise hs-cTnT levels were consistently lower following RIPC (18 ± 3 vs 21 ± 3; 19 ± 3 vs 23 ± 3; and 20 ± 2 vs 25 ± 2 ng/L at 0, 1 and 3-h post-exercise, respectively; P < 0.05). There was no main effect of time, trial, or interaction for NT-proBNP and left ventricular EF or RVFAC (all P < 0.05). A main effect of time was evident for E which transiently declined immediately after exercise to a similar level in both trials (0.85 ± 0.04 vs 0.74 ± 0.04 m/s, respectively; P < 0.05). In summary, RIPC was associated with lower hs-cTnT levels after exercise but there was no independent effect of RIPC for NT-proBNP or LV systolic and diastolic function. The lower hs-cTnT levels after RIPC suggests that further research should evaluate the role of ischemia in exercise-induced elevation in hs-cTnT.
| Item Type: | Article |
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| Additional Information: | This is the accepted version of the following article:Cocking, S., Landman, T., Benson, M., Lord, R., Jones, H., Gaze, D., Thijssen, D. H. J. and George, K. (2016), The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise. Scandinavian Journal of Medicine & Science in Sports. doi: 10.1111/sms.12724, which has been published in final form at http://dx.doi.org/10.1111/sms.12724 |
| Uncontrolled Keywords: | 1106 Human Movement And Sports Science |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wiley |
| Related URLs: | |
| Date Deposited: | 27 Jul 2016 08:24 |
| Last Modified: | 04 Sep 2021 12:40 |
| DOI or ID number: | 10.1111/sms.12724 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/3946 |
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