Awad, K, Penson, P and Banach, M (2016) D-003 (Saccharum officinarum): The forgotten lipid-lowering agent. Pharmacological Research, 114. pp. 42-46. ISSN 1096-1186

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Abstract

Reduction of elevated cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C), is essential in primary and secondary prevention of cardiovascular disease (CVD). Therefore there is still a large need for new effective drugs, which would be able to essentially reduce LDL-C and in the consequence CV residual risk. D-003 is a mixture of high aliphatic primary acids purified from sugarcane (Saccharum officinarum) wax. It showed promising hypocholesterolemic effects in both animal and human studies; it significantly lowers both serum total cholesterol (TC) and LDL-C, and increases high-density lipoprotein cholesterol (HDL-C). In addition, it showed a favorable safety profile. In this review, we evaluated the profile of D-003 as a lipid-lowering agent based on data from available preclinical and clinical studies.

Item Type:	Article
Uncontrolled Keywords:	1115 Pharmacology And Pharmaceutical Sciences
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Elsevier
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/27751878
Date Deposited:	12 Dec 2016 10:32
Last Modified:	20 Apr 2022 09:22
DOI or ID number:	10.1016/j.phrs.2016.10.008
URI:	https://researchonline.ljmu.ac.uk/id/eprint/4676

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