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Joo, CH, Allan, R, Drust, B, Close, GL, Jeong, TS, Bartlett, JD, Mawhinney, C, Louhelainen, J, Morton, JP and Gregson, W (2016) Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle. European Journal of Applied Physiology, 116 (11-12). pp. 2315-2326. ISSN 1439-6327
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Abstract
PURPOSE: We tested the hypothesis that both post-exercise and passive cold water immersion (CWI) increases PGC-1α and VEGF mRNA expression in human skeletal muscle. METHOD: Study 1 Nine males completed an intermittent running protocol (8 × 3-min bouts at 90 % [Formula: see text], interspersed with 3-min active recovery (1.5-min at 25 % and 1.5-min at 50 % [Formula: see text]) before undergoing CWI (10 min at 8 °C) or seated rest (CONT) in a counterbalanced, randomised manner. Study 2 Ten males underwent an identical CWI protocol under passive conditions. RESULTS: Study 1 PGC-1α mRNA increased in CONT (~3.4-fold; P < 0.001) and CWI (~5.9-fold; P < 0.001) at 3 h post-exercise with a greater increase observed in CWI (P < 0.001). VEGFtotal mRNA increased after CWI only (~2.4-fold) compared with CONT (~1.1-fold) at 3 h post-exercise (P < 0.01). Study 2 Following CWI, PGC-1α mRNA expression was significantly increased ~1.3-fold (P = 0.001) and 1.4-fold (P = 0.0004) at 3 and 6 h, respectively. Similarly, VEGF165 mRNA was significantly increased in CWI ~1.9-fold (P = 0.03) and 2.2-fold (P = 0.009) at 3 and 6 h post-immersion. CONCLUSIONS: Data confirm post-exercise CWI augments the acute exercise-induced expression of PGC-1α mRNA in human skeletal muscle compared to exercise per se. Additionally CWI per se mediates the activation of PGC-1α and VEGF mRNA expression in human skeletal muscle. Cold water may therefore enhance the adaptive response to acute exercise.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1106 Human Movement And Sports Science |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Pharmacy & Biomolecular Sciences Sport & Exercise Sciences |
| Publisher: | Springer Verlag |
| Related URLs: | |
| Date Deposited: | 02 Nov 2016 13:18 |
| Last Modified: | 04 Sep 2021 12:20 |
| DOI or ID number: | 10.1007/s00421-016-3480-1 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/4728 |
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