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Owens, DJ, Tang, JCY, Bradley, WJ, Sparks, SA, Fraser, WD, Morton, JP and Close, GL (2016) Efficacy of High Dose Vitamin D Supplements for Elite Athletes. Medicine and Science in Sports and Exercise. ISSN 1530-0315
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Efficacy of High Dose Vitamin D Supplements for Elite Athletes..pdf - Accepted Version Download (569kB) | Preview |
Abstract
PURPOSE: Supplementation with dietary forms of vitamin D is commonplace in clinical medicine, elite athletic cohorts and the general population, yet the response of all major vitamin D metabolites to high doses of vitamin D is poorly characterized. We aimed to identify the responses of all major vitamin D metabolites to moderate and high dose supplemental vitamin D3. METHODS: A repeated measures design was implemented in which 46 elite professional European athletes were block randomized based on their basal 25[OH]D concentration into two treatment groups. Athletes received either 35,000 or 70,000 IU.week vitamin D3 for 12 weeks and 42 athletes completed the trial. Blood samples were collected over 18 weeks to monitor the response to supplementation and withdrawal from supplementation. RESULTS: Both doses led to significant increases in serum 25[OH]D and 1,25[OH]2D3. 70,000 IU.week also resulted in a significant increase of the metabolite 24,25[OH]2D at weeks 6 and 12 that persisted following supplementation withdrawal at week 18, despite a marked decrease in 1,25[OH]2D3. Intact PTH was decreased in both groups by week 6 and remained suppressed throughout the trial. CONCLUSIONS: High dose vitamin D3 supplementation (70,000 IU.week) may be detrimental for its intended purposes due to increased 24,25[OH]2D production. Rapid withdrawal from high dose supplementation may inhibit the bioactivity of 1,25[OH]2D3 as a consequence of sustained increases in 24,25[OH]2D that persist as 25[OH]D and 1,25[OH]2D concentrations decrease. These data imply that lower doses of vitamin D3 ingested frequently may be most appropriate and gradual withdrawal from supplementation as opposed to rapid withdrawal may be favorable.
| Item Type: | Article |
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| Additional Information: | This is a non-final version of an article published in final form in Efficacy of High Dose Vitamin D Supplements for Elite Athletes, Owens et al. Medicine and Science in Sports and Exercise.http://dx.doi.org/10.1249/MSS.0000000000001105 |
| Uncontrolled Keywords: | 1106 Human Movement And Sports Science |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | American College of Sports Medicine |
| Related URLs: | |
| Date Deposited: | 11 Nov 2016 10:03 |
| Last Modified: | 04 Sep 2021 12:18 |
| DOI or ID number: | 10.1249/MSS.0000000000001105 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/4786 |
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