Chasland, LC, Knuiman, MW, Divitini, ML, Chan, YX, Handelsman, DJ, Naylor, LH, Green, DJ and Yeap, BB (2017) Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men. Clinical Endocrinology. ISSN 0300-0664

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Abstract

CONTEXT: Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts with hormones to modify CVD risk is unclear. OBJECTIVE: We assessed whether PA and sex hormone concentrations were independently associated with measures of CVD risk. PARTICIPANTS: 1,649 men. METHODS: Leisure, home, work and total PA were ascertained. At baseline, serum T, dihydrotestosterone (DHT) and estradiol (E2) were assayed. Men were stratified into high PA+high hormone (H/H); low PA+high hormone (L/H); high PA+low hormone (H/L) and low PA+low hormone (L/L). RESULTS: Mean age was 49.8 years at outset with 415 CVD events and 127 CVD deaths occurring during 20-year follow-up. Men with higher PA and higher T or DHT had lower odds of metabolic syndrome (eg. leisure H/H vs L/L odds ratio [OR] 0.17 p<0.001 for T, 0.26 p<0.001 for DHT). Men with higher PA and E2 had lower risk of metabolic syndrome (eg. leisure PA H/H vs L/L OR 0.51, p=0.001). Men with higher leisure, work or total PA and higher DHT had the lowest risk of CVD death (eg. leisure H/H HR 0.55 vs L/L, p=0.033). Men with lower leisure, home or work PA and higher E2 were at greater risk of CVD death (eg. leisure L/H HR 1.60 vs L/L, p=0.039). CONCLUSIONS: Considering T, DHT and E2 in the context of PA better informs consideration of cardiovascular risk. A 2x2 factorial RCT assessing PA and androgens would illuminate the scope for preventing CVD in men. This article is protected by copyright. All rights reserved.

Item Type:	Article
Additional Information:	This is the accepted version of the following article: Chasland, L. C., Knuiman, M. W., Divitini, M. L., Chan, Y. X., Handelsman, D. J., Naylor, L. H., Green, D. J. and Yeap, B. B. (), Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men. Clin Endocrinol. Accepted Author Manuscript. doi:10.1111/cen.13407, which has been published in final form at http://dx.doi.org/10.1111/cen.13407
Uncontrolled Keywords:	1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	Wiley
Related URLs:	Author
Date Deposited:	05 Jul 2017 09:05
Last Modified:	04 Sep 2021 11:22
DOI or ID number:	10.1111/cen.13407
URI:	https://researchonline.ljmu.ac.uk/id/eprint/6781

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