Tools
Tools
Gawthrop, PJ, Siekmann, I, Kameneva, T, Saha, S, Ibbotson, MR and Crampin, EJ (2017) Bond graph modelling of chemoelectrical energy transduction. IET Systems Biology, 11 (5). pp. 127-138. ISSN 1751-8849
|
Text
Bond graph modelling of chemoelectrical energy transduction.pdf - Accepted Version Download (706kB) | Preview |
Abstract
Energy-based bond graph modelling of biomolecular systems is extended to include chemoelectrical transduction thus enabling integrated thermodynamically-compliant modelling of chemoelectrical systems in general and excitable membranes in particular. Our general approach is illustrated by recreating a well-known model of an excitable membrane. This model is used to investigate the energy consumed during a membrane action potential thus contributing to the current debate on the trade-off between the speed of an action potential event and energy consumption. The influx of Na+ is often taken as a proxy for energy consumption; in contrast, this paper presents an energy based model of action potentials. As the energy based approach avoids the assumptions underlying the proxy approach it can be directly used to compute energy consumption in both healthy and diseased neurons. These results are illustrated by comparing the energy consumption of healthy and degenerative retinal ganglion cells using both simulated and in vitro data.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0601 Biochemistry And Cell Biology, 0906 Electrical And Electronic Engineering |
| Subjects: | Q Science > QA Mathematics Q Science > QD Chemistry |
| Divisions: | Applied Mathematics (merged with Comp Sci 10 Aug 20) |
| Publisher: | Institution of Engineering and Technology (IET) |
| Related URLs: | |
| Date Deposited: | 02 Oct 2017 11:01 |
| Last Modified: | 21 Mar 2022 10:30 |
| DOI or ID number: | 10.1049/iet-syb.2017.0006 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/7255 |
 |
View Item |