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Thijssen, DHJ, Redington, A, George, KP, Hopman, MTE and Jones, H (2017) Association of Exercise Preconditioning With Immediate Cardioprotection: A Review. JAMA Cardiology. ISSN 2380-6583
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Thijssen_IPC-exercise_JAMA Cardiol_R3_unmarked.pdf - Accepted Version Download (878kB) | Preview |
Abstract
Importance: Exercise reduces the risk of cardiovascular events, including through an underrecognized, clinically useful form of acute cardioprotection accessible after a single episode of exercise, which is called cardiovascular preconditioning. Observations: Preclinical evidence shows that 1 to 3 episodes of exercise per week will provide strong cardioprotection; gradual, modest cardiovascular risk factor modification or physiological artery remodeling cannot fully explain these benefits. This review highlights preclinical evidence that acute exercise-induced cardiac preconditioning has the ability to activate multiple pathways to confer immediate protection against ischemic events, reduce the severity of potentially lethal ischemic myocardiac injury, and act as a physiological first line of defense. Conclusions and Relevance: Independent of the protective benefits of long-term exercise training on risk factors and adaptation of the cardiovascular system, cardiovascular preconditioning may contribute to the immediate cardioprotection of exercise. In practical terms, this means that 1 episode of exercise can create clinically relevant cardioprotection.
| Item Type: | Article |
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| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | American Medical Association |
| Related URLs: | |
| Date Deposited: | 08 Dec 2017 13:36 |
| Last Modified: | 04 Sep 2021 10:55 |
| DOI or ID number: | 10.1001/jamacardio.2017.4495 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/7689 |
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