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Bnyan, R, Khan, I, Ehtezazi, T, Saleem, I, Gordon, S, Neill, FO and Roberts, M (2018) Surfactant effects on lipid-based vesicles properties. Journal of Pharmaceutical Sciences. ISSN 0022-3549
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Surfactant effects on lipid-based vesicles properties..pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (787kB) | Preview |
Abstract
Understanding the effect of surfactant properties is critical when designing vesicular delivery systems. This review evaluates previous studies to explain the influence of surfactant properties on the behaviour of lipid vesicular systems, specifically their size, charge, stability, entrapment efficiency (EE), pharmacokinetics, and pharmacodynamics. Generally, the size of vesicles decreases by increasing the surfactant concentration, carbon chain length, the hydrophilicity of the surfactant head group, and the hydrophilic-lipophilic balance (HLB). Increasing surfactant concentration can also lead to an increase in charge, which in turn reduces vesicle aggregation and enhances the stability of the system. The vesicles entrapment efficiency not only depends on the surfactant properties but also on the encapsulated drug. For example, the encapsulation of a lipophilic drug could be enhanced by using a surfactant with a low HLB value. Moreover, the membrane permeability of vesicles depends on the surfactant's carbon chain length and transition temperature (Tc). Additionally, surfactants have a clear influence on pharmacokinetics and pharmacodynamics such as sustaining drug release, enhancing the circulation time of vesicles, improving targeting and cellular uptake.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1115 Pharmacology And Pharmaceutical Sciences |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Elsevier |
| Related URLs: | |
| Date Deposited: | 29 Jan 2018 10:58 |
| Last Modified: | 04 Sep 2021 10:49 |
| DOI or ID number: | 10.1016/j.xphs.2018.01.005 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/7907 |
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