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Guetchueng, ST, Nahar, L, Ritchie, KJ, Ismail, FMD, Evans, AR and Sarker, SD (2018) ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex. Hutch. and Assessment of their Cytotoxicity Against Human Cancer Cell Lines. Molecules, 23 (2). ISSN 1420-3049
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ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex Hutch and Assessment of their Cytotoxicity Against Human Cancer Cell Lines.pdf - Published Version Available under License Creative Commons Attribution. Download (457kB) | Preview |
Abstract
New clerodane diterpenes, 12-epi-megalocarpodolide D (2) and an epimeric mixture of crotonolins A (3) and B (4), were isolated from the bark of Croton oligandrus following a bioassay-guided isolation protocol. Known compounds, megalocarpodolide D (1), 12-epi-crotocorylifuran (5), cluytyl-ferulate (6), hexacosanoyl- ferulate (7), vanillin (8), acetyl-aleuritolic acid (9) and lupeol (10), were also isolated. The structures of the isolated compounds (1-10) were elucidated by spectroscopic means. The cytotoxicity of compounds 1-10 was assessed against A549, MCF7, PC3 and PNT2 cell lines using the MTT assay. Compounds 1 and 2 showed moderate level of activity against both A549 and MCF7 cells with 1 being the most active with IC50 values of 63.8±13.8 and 136.2±22.7 µM against A549 and MCF7 cells, respectively. The epimeric mixture of 3 and 4 was moderately active against A549 and PC3 cells (IC50 = 128.6±31.0 and 111.2±2.9 µM, respectively).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0305 Organic Chemistry |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | MDPI AG |
| Date Deposited: | 26 Feb 2018 10:12 |
| Last Modified: | 04 Sep 2021 10:47 |
| DOI or ID number: | 10.3390/molecules23020410 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/7996 |
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