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Sharif, H, Ting, S, Forsythe, L, McGregor, G, Banerjee, P, O'Leary, D, Ditor, D, George, KP, Zehnder, D and Oxborough, D (2018) Layer-specific systolic and diastolic strain in hypertensive patients with and without mild diastolic dysfunction. Echo Research and Practice, 5 (1). pp. 41-49. ISSN 2055-0464
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Abstract
This study sought to examine layer-specific longitudinal and circumferential systolic and diastolic strain, strain rate (SR) and diastolic time intervals in hypertensive patients with and without diastolic dysfunction. Fifty-eight treated hypertensive patients were assigned to normal diastolic function (NDF,N = 39) or mild diastolic dysfunction (DD,N = 19) group. Layer-specific systolic and diastolic longitudinal and circumferential strains and SR were assessed. Results showed no between-group difference in left ventricular mass index (DD: 92.1 ± 18.1 vs NDF: 88.4 ± 16.3;P = 0.44). Patients with DD had a proportional reduction in longitudinal strain across the myocardium (endocardial for DD -13 ± 4%; vs NDF -17 ± 3,P < 0.01; epicardial for DD -10 ± 3% vs NDF -13 ± 3%,P < 0.01; global for DD: -12 ± 3% vs NDF: -15 ± 3,P = 0.01), and longitudinal mechanical diastolic impairments as evidenced by reduced longitudinal strain rate of early diastole (DD 0.7 ± 0.2 L/s vs NDF 1.0 ± 0.3 L/s,P < 0.01) and absence of a transmural gradient in the duration of diastolic strain (DD endocardial: 547 ± 105 ms vs epicardial: 542 ± 113 ms,P = 0.24; NDF endocardial: 566 ± 86 ms vs epicardial: 553 ± 77 ms,P = 0.03). Patients with DD also demonstrate a longer duration of early circumferential diastolic strain (231 ± 71 ms vs 189 ± 58 ms,P = 0.02). In conclusion, hypertensive patients with mild DD demonstrate a proportional reduction in longitudinal strain across the myocardium, as well as longitudinal mechanical diastolic impairment, and prolonging duration of circumferential mechanical relaxation.
| Item Type: | Article |
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| Uncontrolled Keywords: | diastolic dysfunction; hypertension; layer-specific strain; transmural gradient |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Bio Scientifica |
| Related URLs: | |
| Date Deposited: | 26 Mar 2018 10:31 |
| Last Modified: | 04 Sep 2021 10:37 |
| DOI or ID number: | 10.1530/ERP-17-0072 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/8371 |
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