Tools
Tools
Hughes, ATL, Croft, CL, Samuels, RE, Myung, J, Takumi, T and Piggins, HD (2015) Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC(2)-signaling deficient mice. Scientific Reports, 5. ISSN 2045-2322
|
Text
Hughes et al (2015) LL improves VPAC2KO rhythms FINAL PUBLISHED.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and use intercellular signaling to synchronize their timekeeping activities so that the SCN can coordinate brain physiology and behavior. The neuropeptide vasoactive intestinal polypeptide (VIP) and its VPAC2 receptor form a key component of intercellular signaling systems in the SCN and critically control cellular coupling. Targeted mutations in either the intracellular clock or intercellular neuropeptide signaling mechanisms, such as VIP-VPAC2 signaling, can lead to desynchronization of SCN neuronal clocks and loss of behavioral rhythms. An important goal in chronobiology is to develop interventions to correct deficiencies in circadian timekeeping. Here we show that extended exposure to constant light promotes synchrony among SCN clock cells and the expression of ~24 h rhythms in behavior in mice in which intercellular signaling is disrupted through loss of VIP-VPAC2 signaling. This study highlights the importance of SCN synchrony for the expression of rhythms in behavior and reveals how non-invasive manipulations in the external environment can be used to overcome neurochemical communication deficits in this important brain system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; VASOACTIVE-INTESTINAL-PEPTIDE; MOUSE SUPRACHIASMATIC NUCLEUS; VPAC(2) RECEPTOR; CELLULAR RHYTHMICITY; LOCOMOTOR-ACTIVITY; PHOTIC REGULATION; GENE-EXPRESSION; MPER2 PROTEIN; MUTANT MICE; NEURONS |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Natural Sciences & Psychology (closed 31 Aug 19) |
| Publisher: | Nature Publishing Group |
| Date Deposited: | 05 Apr 2018 10:18 |
| Last Modified: | 04 Sep 2021 02:47 |
| DOI or ID number: | 10.1038/srep14044 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/8417 |
 |
View Item |