Baumert, P, G-REX Consortium, , Stewart, CE, Lake, MJ, Drust, B and Erskine, RM (2018) Variations of Collagen-Encoding Genes are Associated with Exercise-Induced Muscle Damage. Physiological Genomics, 50 (9). pp. 691-693. ISSN 1094-8341

Full text not available from this repository. Please see publisher or open access link below:

Abstract

We investigated whether single nucleotide polymorphisms (SNPs) within genes encoding the alpha-1 chain of type I (COL1A1, rs2249492; rs1800012), type II (COL2A1, rs2070739) and type V (COL5A1, rs12722) collagen were associated with the variable response to exercise-induced muscle damage (EIMD). Knee extensor muscle strength and soreness were assessed pre-, post-, and 48h post-EIMD (120 maximal eccentric knee extensor contractions) in 65 young healthy participants, who were genotyped for the aforementioned SNPs. We found that COL1A1 (minor) T-allele carriers (rs1800012) and (major) T-allele homozygotes (rs2249492) were generally weaker (p≤0.019); and (minor) A-allele carriers of COL2A1 (p=0.002) and (major) T-allele carriers COL5A1 (p=0.004) SNPs reported greater muscle soreness, all compared to their respective major (rs1800012; rs2070739) and minor (rs2249492; rs12722) allele homozygote counterparts. To conclude, the risk alleles of these four SNPs appear to negatively influence muscle strength and post-EIMD recovery, possibly via a dysregulated collagen network affecting the muscle’s mechanical properties.

Item Type:	Article
Uncontrolled Keywords:	1116 Medical Physiology
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	American Physiological Society
Related URLs:	https://www.ljmu.ac.uk/about-us/staff-profiles/faculty-of-science/sport-and-exercise-sciences/robert-erskine
Date Deposited:	22 May 2018 10:49
Last Modified:	03 Sep 2021 21:04
DOI or ID number:	10.1152/physiolgenomics.00145.2017
URI:	https://researchonline.ljmu.ac.uk/id/eprint/8696

View Item