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Omondi, RO, Ojwach, SO, Jaganyi, D and Fatokun, AA (2018) (Pyrazolyl)pyridine ruthenium(III) complexes: Synthesis, kinetics of substitution reactions with thiourea and biological studies. INORGANIC CHEMISTRY COMMUNICATIONS, 94. pp. 98-103. ISSN 1387-7003
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Abstract
Reactions of 2-bromo-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine (L1), 2,6-di (1H-pyrazol-1-yl) pyridine (L2) and 2,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)pyridine (L3) with RuCl3·3H2O led to the formation of their respective metal complexes [RuCl3(L1)] (1), [RuCl3(L2)] (2) and [RuCl3(L3)] (3). Solid state structure of complex 3 established the formation of a six-coordinate mononuclear compound in which L3 is tridentately bound. The order of reactivity of the studied complexes with thiourea (TU) nucleophile is in the form 1?>?2?>?3, in line with density functional theory (DFT) studies. The complexes displayed minimal cytotoxic activity against the HeLa cell line, consistent with molecular docking experiments which showed weaker DNA binding affinities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0302 Inorganic Chemistry, 0399 Other Chemical Sciences |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | ELSEVIER SCIENCE BV |
| Related URLs: | |
| Date of acceptance: | 2 June 2018 |
| Date of first compliant Open Access: | 19 June 2019 |
| Date Deposited: | 11 Sep 2018 10:33 |
| Last Modified: | 04 Sep 2021 10:07 |
| DOI or ID number: | 10.1016/j.inoche.2018.06.006 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/9199 |
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