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The relationship between CSF tau markers, hippocampal volume and delayed primacy performance in cognitively intact elderly individuals.

Bruno, D and Grothe, MJ and Nierenberg, J and Teipel, SJ and Zetterberg, H and Blennow, K and Pomara, N (2015) The relationship between CSF tau markers, hippocampal volume and delayed primacy performance in cognitively intact elderly individuals. Alzheimer's & Dementia, 1 (1). pp. 81-86. ISSN 2352-8729

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Abstract

BACKGROUND: Primacy performance in recall has been shown to predict cognitive decline in cognitively intact elderly, and conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Delayed primacy performance, but not delayed non-primacy performance, has been shown to be associated with hippocampal volume in cognitively intact older individuals. Since presence of neurofibrillary tangles is an early sign of AD-related pathology, we set out to test whether cerebrospinal fluid (CSF) levels of tau had an effect on delayed primacy performance, while controlling for hippocampal volume and CSF Aβ 1-42 levels. METHODS: Forty-seven individuals, 60 or older and cognitively intact, underwent a multi-session study including lumbar puncture, an MRI scan of the head and memory testing. RESULTS: Our regression analyses show that CSF levels of hyperphosphorylated (P) tau are only associated with reduced delayed primacy performance when hippocampal volumes are smaller. CONCLUSION: Our findings suggest that hippocampal size may play a protective role against the negative effects of P tau on memory.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease; Amyloid β 1-42; CSF Biomarkers; Hippocampus; Memory; Primacy; Serial Position; Tau
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Natural Sciences and Psychology
Publisher: Elsevier
Related URLs:
Date Deposited: 09 Feb 2016 13:22
Last Modified: 29 Mar 2016 23:50
DOI or Identification number: 10.1016/j.dadm.2014.11.002
URI: http://researchonline.ljmu.ac.uk/id/eprint/2888

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