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Cytotoxicity, In vitro anti-Leishmanial and fingerprint HPLC- photodiode array analysis of the roots of Trillium govanianum.

Khan, KM and Nahar, L and Mannan, A and Ul-Haq, I and Arfan, M and Ali Khan, G and Hussain, I and Sarker, SD (2017) Cytotoxicity, In vitro anti-Leishmanial and fingerprint HPLC- photodiode array analysis of the roots of Trillium govanianum. Natural Product Research. ISSN 1478-6419

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Abstract

Trillium govanianum Wall. ex D. Don (Melanthiaceae alt. Trilliaceae), commonly known as 'nagchhatry' or 'teen patra', distributed from Pakistan to Bhutan about 2500-3800 m altitude is indigenous to Himalayas region. In folk medicine the plant has been reported for the treatment of wound healing, sepsis and in various sexual disorders. This paper reports, for the first time, to evaluate the cytotoxicity, in vitro anti-leishmanial (promastigotes) and fingerprint HPLC-photodiode array analysis of the MeOH extract of the roots of T. govanianum and its solid phase extraction fractions. Reverse phase HPLC-PDA based quantification revealed the presence of significant amount of quercetin, myrecetin and kaemferol ranging from 0.221to 0.528 μg/mg DW. MeOH extract revealed distinguishable protein kinase inhibitory activity against Streptomyces 85E strain with 18 mm bald phenotype. The remarkable toxicity profile against brine shrimps and leishmanial was manifested by MeOH extract with LC50 10 and 38.5 μg/mL, respectively.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research on 05th September 2017, available online: http://www.tandfonline.com/10.1080/14786419.2017.1371164
Uncontrolled Keywords: MD Multidisciplinary
Subjects: Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Related URLs:
Date Deposited: 08 Nov 2017 11:34
Last Modified: 08 Nov 2017 11:34
DOI or Identification number: 10.1080/14786419.2017.1371164
URI: http://researchonline.ljmu.ac.uk/id/eprint/7490

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