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Layer-specific systolic and diastolic strain in hypertensive patients with and without mild diastolic dysfunction.

Sharif, H, Ting, S, Forsythe, L, McGregor, G, Banerjee, P, O'Leary, D, Ditor, D, George, KP, Zehnder, D and Oxborough, D (2018) Layer-specific systolic and diastolic strain in hypertensive patients with and without mild diastolic dysfunction. Echo Research and Practice, 5 (1). pp. 41-49. ISSN 2055-0464

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Abstract

This study sought to examine layer-specific longitudinal and circumferential systolic and diastolic strain, strain rate (SR) and diastolic time intervals in hypertensive patients with and without diastolic dysfunction. Fifty-eight treated hypertensive patients were assigned to normal diastolic function (NDF,N = 39) or mild diastolic dysfunction (DD,N = 19) group. Layer-specific systolic and diastolic longitudinal and circumferential strains and SR were assessed. Results showed no between-group difference in left ventricular mass index (DD: 92.1 ± 18.1 vs NDF: 88.4 ± 16.3;P = 0.44). Patients with DD had a proportional reduction in longitudinal strain across the myocardium (endocardial for DD -13 ± 4%; vs NDF -17 ± 3,P < 0.01; epicardial for DD -10 ± 3% vs NDF -13 ± 3%,P < 0.01; global for DD: -12 ± 3% vs NDF: -15 ± 3,P = 0.01), and longitudinal mechanical diastolic impairments as evidenced by reduced longitudinal strain rate of early diastole (DD 0.7 ± 0.2 L/s vs NDF 1.0 ± 0.3 L/s,P < 0.01) and absence of a transmural gradient in the duration of diastolic strain (DD endocardial: 547 ± 105 ms vs epicardial: 542 ± 113 ms,P = 0.24; NDF endocardial: 566 ± 86 ms vs epicardial: 553 ± 77 ms,P = 0.03). Patients with DD also demonstrate a longer duration of early circumferential diastolic strain (231 ± 71 ms vs 189 ± 58 ms,P = 0.02). In conclusion, hypertensive patients with mild DD demonstrate a proportional reduction in longitudinal strain across the myocardium, as well as longitudinal mechanical diastolic impairment, and prolonging duration of circumferential mechanical relaxation.

Item Type: Article
Uncontrolled Keywords: diastolic dysfunction; hypertension; layer-specific strain; transmural gradient
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Bio Scientifica
Related URLs:
Date Deposited: 26 Mar 2018 10:31
Last Modified: 26 Mar 2018 10:31
DOI or Identification number: 10.1530/ERP-17-0072
URI: http://researchonline.ljmu.ac.uk/id/eprint/8371

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