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Variations of Collagen-Encoding Genes are Associated with Exercise-Induced Muscle Damage

Baumert, P, G-REX Consortium, , Stewart, CE, Lake, MJ, Drust, B and Erskine, RM Variations of Collagen-Encoding Genes are Associated with Exercise-Induced Muscle Damage. Physiological Genomics. ISSN 1094-8341 (Accepted)

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Abstract

We investigated whether single nucleotide polymorphisms (SNPs) within genes encoding the alpha-1 chain of type I (COL1A1, rs2249492; rs1800012), type II (COL2A1, rs2070739) and type V (COL5A1, rs12722) collagen were associated with the variable response to exercise-induced muscle damage (EIMD). Knee extensor muscle strength and soreness were assessed pre-, post-, and 48h post-EIMD (120 maximal eccentric knee extensor contractions) in 65 young healthy participants, who were genotyped for the aforementioned SNPs. We found that COL1A1 (minor) T-allele carriers (rs1800012) and (major) T-allele homozygotes (rs2249492) were generally weaker (p≤0.019); and (minor) A-allele carriers of COL2A1 (p=0.002) and (major) T-allele carriers COL5A1 (p=0.004) SNPs reported greater muscle soreness, all compared to their respective major (rs1800012; rs2070739) and minor (rs2249492; rs12722) allele homozygote counterparts. To conclude, the risk alleles of these four SNPs appear to negatively influence muscle strength and post-EIMD recovery, possibly via a dysregulated collagen network affecting the muscle’s mechanical properties.

Item Type: Article
Uncontrolled Keywords: 1116 Medical Physiology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American Physiological Society
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Date Deposited: 22 May 2018 10:49
Last Modified: 22 May 2018 10:49
URI: http://researchonline.ljmu.ac.uk/id/eprint/8696

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