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The Acute Impact of Changes to Haemodynamic Load on the Left Ventricular Strain-Volume Relationship in Young and Older Men.

Hulshof, HG, van Dijk, APJ, Hopman, MTE, van der Sluijs, CF, George, KP, Oxborough, DL and Thijssen, DHJ (2020) The Acute Impact of Changes to Haemodynamic Load on the Left Ventricular Strain-Volume Relationship in Young and Older Men. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. ISSN 0363-6119

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Abstract

OBJECTIVES: Chronic changes in left ventricular (LV) haemodynamics, for example induced by increased afterload (i.e., hypertension), mediate changes in LV function. This study examined the proof-of-concept that: 1. the LV longitudinal strain (ԑ)-volume loop is sensitive to detect an acute increase in afterload, and 2. these effects differ between healthy young versus older men. METHODS: Thirty-five healthy male volunteers were recruited including 19 young (24±2 yr) and 16 older participants (67±5 yr). Tests were performed prior to, during and after 10-min recovery from acute manipulation of afterload. Real-time haemodynamic data was obtained and LV longitudinal ԑ-volume loops were calculated from 4-chamber images using 2D-echocardiography. RESULTS: Inflation of the anti-G-suit resulted in an immediate increase in heart rate, blood pressure and systemic vascular resistance, and a decrease in stroke volume (all P<0.05). This was accompanied by a decrease in LV peak ԑ, slower slope of the ԑ-volume relationship during early diastole, increase in uncoupling (i.e., compared to systole; little change in ԑ per volume decline during early diastole and large changes in ԑ per volume decline during late diastole) (all P<0.05). All values returned to baseline levels after recovery (all P>0.05). Manipulation of cardiac haemodynamics caused comparable effects in young versus older men (all P>0.05). CONCLUSIONS: Acute increases in afterload immediately change the diastolic phase of the LV longitudinal ԑ-volume loop in young and older men. This supports the potency of the LV longitudinal ԑ-volume loop to provide novel insights into dynamic cardiac function in humans in vivo.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 11 Medical and Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sports & Exercise Sciences
Publisher: American Physiological Society
Related URLs:
Date Deposited: 18 Feb 2020 12:17
Last Modified: 18 Feb 2020 12:30
DOI or Identification number: 10.1152/ajpregu.00215.2019
URI: http://researchonline.ljmu.ac.uk/id/eprint/12276

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