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Coenzyme Q10 Assessment and the Establishment of a Neuronal Cell Model of CoQ10 Deficiency

Heaton, R, Duberley, K and Hargreaves, IP (2020) Coenzyme Q10 Assessment and the Establishment of a Neuronal Cell Model of CoQ10 Deficiency. In: guest, P, (ed.) Clinical and Preclinical Models for Maximizing Healthspan. Springer, pp. 277-287. ISBN 978-1-07-160471-7

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Abstract

Coenzyme Q10 (CoQ10) plays a key role as an electron carrier in the mitochondrial respiratory chain and as a cellular antioxidant molecule. A deficit in CoQ10 status may contribute to disease pathophysiology by causing a failure mitochondrial energy metabolism as well as compromising cellular antioxidant capacity. This chapter outlines the analytical methods used for determining cellular CoQ10 status using high-pressure liquid chromatography with ultraviolet (HPLC-UV) detection. In addition, we present a pharmacological procedure for establishing a human neuronal cell model of CoQ10 deficiency, for use in research studies.

Item Type: Book Section
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Springer
Date Deposited: 30 Mar 2020 11:39
Last Modified: 30 Mar 2020 11:39
DOI or Identification number: 10.1007/978-1-0716-0471-7_19
Editors: guest, P
URI: http://researchonline.ljmu.ac.uk/id/eprint/12610

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