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The role of the metabotropic glutamate receptor 5 in nicotine addiction.

Akkus, F, Terbeck, S, Haggarty, CJ, Treyer, V, Dietrich, JJ, Hornschuh, S and Hasler, G (2020) The role of the metabotropic glutamate receptor 5 in nicotine addiction. CNS Spectrums. ISSN 1092-8529

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Abstract

This review summarizes the evidence for the potential involvement of metabotropic glutamate receptor 5 (mGluR5) in the development of nicotine addiction. Nicotine is consumed worldwide and is highly addictive. Previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has provided strong evidence for the involvement of dopaminergic neuronal circuitry in nicotine addiction. More recently, researchers focused on glutamatergic transmission after nicotine abuse, and its involvement in the reinforcing and rewarding effects of nicotine addiction. A number of robust preclinical and clinical studies have shown mGluR5 signaling as a facilitating mechanism of nicotine addiction and nicotine withdrawal. Specifically, clinical studies have illustrated lower cortical mGluR5 density in smokers compared to non-smokers in the human brain. In addition, mGluR5 might selectively regulate craving and withdrawal. This suggests that mGluR5 could be a key receptor in the development of nicotine addiction and therefore clinical trials to examine the therapeutic potential of mGluR5 agents could help to contribute to reduce nicotine addiction in society.

Item Type: Article
Additional Information: This is the accepted version of the following paper: Akkus, F., Terbeck, S., Haggarty, C., Treyer, V., Dietrich, J., Hornschuh, S., & Hasler, G. (2020). The role of the metabotropic glutamate receptor 5 in nicotine addiction. CNS Spectrums, 1-15. doi:10.1017/S1092852920001704
Uncontrolled Keywords: 1103 Clinical Sciences, 1109 Neurosciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (new Sep 2019)
Publisher: Cambridge University Press
Related URLs:
Date Deposited: 06 Aug 2020 10:47
Last Modified: 06 Aug 2020 10:47
DOI or Identification number: 10.1017/S1092852920001704
URI: https://researchonline.ljmu.ac.uk/id/eprint/13456

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