Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE‐ABC): study protocol for a multi‐centre randomised controlled trial

Hernon, J and Thomas, LB SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE‐ABC): study protocol for a multi‐centre randomised controlled trial. Colorectal Disease. ISSN 1462-8910 (Accepted)

[img] Text
SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE‐ABC) study protocol for a multi‐centre randomised controlled trial.pdf - Accepted Version
Restricted to Repository staff only

Download (815kB)

Abstract

Background: Exercise programmes can increase cardiopulmonary reserve and functional capacity prior to surgery and can improve clinical, functional and survival outcomes after a colorectal cancer diagnosis. However, the impact of pre- and post-operative exercise on post-operative recovery outcomes and longer-term health-related quality of life are unknown, thus there is a need for high quality randomised controlled trials.
Method: SupPoRtive Exercise Programmes for Accelerating REcovery after major Abdominal Cancer surgery (PREPARE-ABC) is a 3-arm multi-centre randomised controlled trial with internal pilot. The primary objective is to assess the effects of pre- and post-operative exercise on surgical outcomes and longer-term health-related quality of life in cancer patients undergoing colorectal resection. PREPARE-ABC aims to randomise 1146 patients at the individual level (1:1:1) to either hospital-supervised exercise, home-supported exercise or treatment as usual. The primary outcomes are short-term (30-day) morbidity using the Clavien-Dindo classification and longer-term healthrelated quality of life using the Medical Outcomes Study Health Questionnaire (SF-36). Secondary outcomes include cardiopulmonary fitness, physical activity behaviour change, psychological health status and cost-effectiveness. A process evaluation of intervention delivery and usual care also will be undertaken.
Discussion: This is the first UK-based definitive randomised controlled trial to investigate the effects of pre- and post-operative exercise on short-term post-operative health outcomes and longer-term health-related quality of life in colorectal cancer patients. The trial will yield robust clinical and costeffectiveness data to underpin clinical guidance on how exercise programmes should be implemented in the routine management of patients undergoing major colorectal cancer surgery.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Date Deposited: 20 Jul 2021 09:18
Last Modified: 20 Jul 2021 09:30
DOI or Identification number: 10.1111/codi.15805
URI: https://researchonline.ljmu.ac.uk/id/eprint/15305

Actions (login required)

View Item View Item