Pontzer, H, Yamada, Y, Sagayama, H, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SG, Close, GL, Cooper, JA, Cooper, R et al, Das, SK, Dugas, LR, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Martin, C, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Neuhouser, ML, Nicklas, TA, Ojiambo, RM, Pietiläinen, KH, Pitsiladis, YP, Plange-Rhule, J, Plasqui, G, Prentice, RL, Rabinovich, RA, Racette, SB, Raichlen, DA, Ravussin, E, Reynolds, RM, Roberts, SB, Schuit, AJ, Sjödin, AM, Stice, E, Urlacher, SS, Valenti, G, Van Etten, LM, Van Mil, EA, Wells, JCK, Wilson, G, Wood, BM, Yanovski, J, Yoshida, T, Zhang, X, Murphy-Alford, AJ, Loechl, C, Luke, AH, Rood, J, Schoeller, DA, Westerterp, KR, Wong, WW, Speakman, JR and IAEA DLW Database Consortium, (2021) Daily energy expenditure through the human life course. Science, 373 (6556). ISSN 0036-8075

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Abstract

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Item Type:	Article
Additional Information:	This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 13/08/2021 Vol 373, DOI: https://dx.doi.org/10.1126/science.abe5017
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	American Association for the Advancement of Science
Related URLs:	Author
Date Deposited:	19 Aug 2021 10:05
Last Modified:	04 Sep 2021 05:08
DOI or ID number:	10.1126/science.abe5017
URI:	https://researchonline.ljmu.ac.uk/id/eprint/15386

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