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Physical activity assessment and vascular function in adults with cystic fibrosis and their non-CF peers

Shelley, J, Boddy, L, Knowles, Z, Stewart, C, Frost, F, Nazareth, D, Walshaw, M and Dawson, E (2022) Physical activity assessment and vascular function in adults with cystic fibrosis and their non-CF peers. Journal of Sports Sciences, 40 (16). pp. 1837-1848. ISSN 1466-447X

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An understanding of physical activity (PA) and related health benefits remains limited in adults with Cystic Fibrosis (CF). Raw acceleration data metrics may improve the quality of assessment and further this understanding. The study aimed to compare PA between people with CF (pwCF) and non-CF peers and examine associations between PA, vascular function and health outcome measures. PA was assessed in 62 participants (31 pwCF) using ActiGraph accelerometers. Vascular function (a marker of cardiovascular disease risk) was assessed using flow-mediated dilatation (FMD) in sub-groups of pwCF (n = 12) and matched controls. Average Euclidean norm minus one (ENMO) (total PA) was significantly lower (p = 0.005) in pwCF (35.09 ± 10.60 mg), than their non-CF peers (44.62 ± 13.78 mg). PwCF had PA profiles (intensity gradient) indicative of more time in lower intensity activity (−2.62 ± 0.20, −2.37 ± 0.23). Vigorous activity was positively associated with lung function (rs  = 0.359) and Quality of Life (r = 0.412). There were no significant differences (p = 0.313) in FMD% between pwCF (5.29 ± 2.76%) and non-CF peers (4.34 ± 1.58%) and no associations with PA. PwCF engaged in less moderate-to-vigorous PA and demonstrated a steeper PA profile than their non-CF peers.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Sport Sciences on 26/08/2022, available at: http://www.tandfonline.com/10.1080/02640414.2022.2115224.
Uncontrolled Keywords: Humans; Cystic Fibrosis; Exercise; Acceleration; Quality of Life; Adult; Cardiovascular; FMD; endothelial function; exercise; flow-mediated dilatation; respiratory disease; Adult; Humans; Cystic Fibrosis; Quality of Life; Exercise; Acceleration; 1106 Human Movement and Sports Sciences; 1302 Curriculum and Pedagogy; Sport Sciences
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Taylor & Francis
SWORD Depositor: A Symplectic
Date Deposited: 23 Jan 2023 16:19
Last Modified: 26 Aug 2023 00:50
DOI or ID number: 10.1080/02640414.2022.2115224
URI: https://researchonline.ljmu.ac.uk/id/eprint/18640
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