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Do antihypertensive medicines increase the risk of depression?

Henney, N and Penson, P (2023) Do antihypertensive medicines increase the risk of depression? The Pharmaceutical Journal, 311. ISSN 2053-6186

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Depression is a common and often debilitating mental health condition that affects a significant proportion of the population. Antihypertensive drugs are prescribed for the pharmacological management of high blood pressure, which affects approximately one third of adults globally. While these drugs are generally well tolerated, concerns remain about the potential risk of depression associated with their use. Several studies have investigated the link between antihypertensive drugs and depression, with mixed results. Some studies have reported an increased risk of depression in patients taking certain classes of antihypertensive drugs, such as beta-blockers and calcium channel blockers; others have found no significant association between these medicines and depression, or report a reduction in risk of depression. Using evidence, this review considers whether any differences in the risk of depression exist between antihypertensive classes or if any particular drugs stand out as being more or less likely to be linked with depression. We found no substantial evidence of any class effect on risk of depression, although lipophilic beta-blockers are associated with increased reports of sleep disturbance and fatigue. Given the high prevalence of hypertension and depression, further well-designed studies are needed to clarify the potential link between antihypertensive drugs and depression.

Item Type: Article
Uncontrolled Keywords: Pharmacology & Pharmacy
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: The Royal Pharmaceutical Society
SWORD Depositor: A Symplectic
Date Deposited: 22 Aug 2023 14:54
Last Modified: 29 Aug 2023 08:09
DOI or Identification number: 10.1211/pj.2023.1.193972
URI: https://researchonline.ljmu.ac.uk/id/eprint/20824

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