Al Akiki Dit Al Mazraani, R, Malys, N and Maliene, V (2025) Itaconate and its derivatives as anti-pathogenic agents. RSC Advances, 15 (6). ISSN 2046-2069

Preview

Text authorreprints_RSC Advances.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

Pathogenic microorganisms and viruses cause outbreaks and pandemics that affect millions of people worldwide. Despite recent advances in pharmacology and medicine, the ability of infectious diseases to spread in the modern era is accelerating due to various factors contributing to increased human-to-human and human–animal contacts. With the global rise of drug resistance among pathogens and frequently occurring viral outbreaks, alternative drugs and therapies that specifically inhibit microbial virulence or regulate immune responses are attracting growing interest. The present review focuses on itaconate and its derivatives as potential anti-pathogenic agents. It summarizes the current state of research on itaconate metabolism in bacteria, fungi and mammals. This is followed by a comprehensive review of recent advances studying itaconate and its derivatives as anti-inflammatory, immunoregulatory, antimicrobial and antiviral compounds, along with their mechanisms of action. Finally, the review emphasises the existing challenges and future research directions for the application of itaconate and its derivatives as anti-pathogenic agents.

Item Type:	Article
Uncontrolled Keywords:	03 Chemical Sciences; 34 Chemical sciences
Subjects:	T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Civil Engineering and Built Environment
Publisher:	The Royal Society of Chemistry
SWORD Depositor:	A Symplectic
Date Deposited:	10 Feb 2025 15:48
Last Modified:	10 Feb 2025 16:00
DOI or ID number:	10.1039/d4ra08298b
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25597

View Item