Yang, X, Li, Y, Bao, D, Yan, B, Mei, T, Liu, X, Cięszczyk, P, Ahmetov, II, Mc Naughton, LR and He, Z (2024) Genomic predictors of fat mass response to the standardized exercise training. International Journal of Sports Medicine, 46 (2). pp. 127-136. ISSN 0172-4622

Text Genomic predictors of fat mass response to the standardized exercise training.pdf - Accepted Version Restricted to Repository staff only until 30 October 2025. Download (1MB)

Abstract

To explore the genetic architecture underlying exercise-induced fat mass change, we performed a genome-wide association study with a Chinese cohort consisting of 442 physically inactive healthy adults in response to a 12-week exercise training (High-intensity Interval Training or Resistance Training). The inter-individual response showed an exercise-induced fat mass change and ten novel lead SNPs were associated with the response on the level of P<1×10 -5. Four of them (rs7187742, rs1467243, rs28629770 and rs10848501) showed a consistent effect direction in the European ancestry. The Polygenic Predictor Score (PPS) derived from ten lead SNPs, sex, baseline body mass and exercise protocols explained 40.3% of the variance in fat mass response, meanwhile importantly the PPS had the greatest contribution. Of note, the subjects whose PPS was lower than -9.301 had the highest response in exercise-induced fat loss. Finally, we highlight a series of pathways and biological processes regarding the fat mass response to exercise, e.g. apelin signaling pathway, insulin secretion pathway and fat cell differentiation biological process.

Item Type:	Article
Additional Information:	© 2024. Thieme. All rights reserved.
Uncontrolled Keywords:	Adipose Tissue; Humans; Insulin; Polymorphism, Single Nucleotide; Adult; Female; Male; Resistance Training; Genome-Wide Association Study; Young Adult; High-Intensity Interval Training; Apelin; Asian People; Humans; Male; Female; Genome-Wide Association Study; Polymorphism, Single Nucleotide; Adult; Resistance Training; High-Intensity Interval Training; Apelin; Adipose Tissue; Insulin; Asian People; Young Adult; 42 Health Sciences; 4207 Sports Science and Exercise; Genetics; Nutrition; Prevention; Physical Activity; Behavioral and Social Science; Human Genome; 2.1 Biological and endogenous factors; Humans; Male; Female; Genome-Wide Association Study; Polymorphism, Single Nucleotide; Adult; Resistance Training; High-Intensity Interval Training; Apelin; Adipose Tissue; Insulin; Asian People; Young Adult; 0913 Mechanical Engineering; 1106 Human Movement and Sports Sciences; Sport Sciences; 4207 Sports science and exercise
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	Thieme Gruppe |
SWORD Depositor:	A Symplectic
Date Deposited:	06 Mar 2025 16:11
Last Modified:	06 Mar 2025 16:15
DOI or ID number:	10.1055/a-2421-9385
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25811

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