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Davies, MJ, Costley, M, Ren, J, Gibbons, P, Kondor, A and Naderi, M (2017) On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing. Journal of 3D Printing in Medicine, 1 (1). pp. 31-47. ISSN 2059-4755
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3D Printing Maunscript vFINAL Sept 2016.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Aim: 3D printing can be applied for point-of-care personalized treatment. This study aimed to determine the manufacturability and characteristics of 3D printed, drug loaded implants for alcohol misuse. Materials & methods: Disulfiram was the drug substance used and polylactic acid (PLA) the base material. Implantable devices were designed in silico. Drug and PLA were placed into the extruder to produce a 5% blend at 1.75-mm diameter. Material characterization included differential scanning calorimetry, thermogravimetric analysis plus inverse GC-surface energy analyzer. Results: Implantable constructs from the PLA feedstock were acquired. The extrusion processes had a detrimental effect on the active pharmaceutical ingredient-base blend. differential scanning calorimetry and thermogravimetric analysis analysis indicated drug–base interactions. Thermal history was found to influence inverse GC probe interaction. Conclusion: Drug-base incompatibilities must be considered during 3D printing.
| Item Type: | Article |
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| Additional Information: | This is an accepted article published in full at: Davies, M.J et al. On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing. Journal of 3D Printing in Medicine. 1(1), pp31-47 DOI: 10.2217/3dp-2016-0006 |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology T Technology > TJ Mechanical engineering and machinery |
| Divisions: | Maritime & Mechanical Engineering (merged with Engineering 10 Aug 20) Pharmacy & Biomolecular Sciences |
| Publisher: | Future Medicine |
| Date Deposited: | 12 Jan 2017 11:58 |
| Last Modified: | 04 Sep 2021 12:06 |
| DOI or ID number: | 10.2217/3dp-2016-0006 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/5254 |
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