Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Surfactant effects on lipid-based vesicles properties.

Bnyan, R, Khan, I, Ehtezazi, T, Saleem, I, Gordon, S, Neill, FO and Roberts, M (2018) Surfactant effects on lipid-based vesicles properties. Journal of Pharmaceutical Sciences. ISSN 0022-3549

Surfactant effects on lipid-based vesicles properties..pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (787kB) | Preview


Understanding the effect of surfactant properties is critical when designing vesicular delivery systems. This review evaluates previous studies to explain the influence of surfactant properties on the behaviour of lipid vesicular systems, specifically their size, charge, stability, entrapment efficiency (EE), pharmacokinetics, and pharmacodynamics. Generally, the size of vesicles decreases by increasing the surfactant concentration, carbon chain length, the hydrophilicity of the surfactant head group, and the hydrophilic-lipophilic balance (HLB). Increasing surfactant concentration can also lead to an increase in charge, which in turn reduces vesicle aggregation and enhances the stability of the system. The vesicles entrapment efficiency not only depends on the surfactant properties but also on the encapsulated drug. For example, the encapsulation of a lipophilic drug could be enhanced by using a surfactant with a low HLB value. Moreover, the membrane permeability of vesicles depends on the surfactant's carbon chain length and transition temperature (Tc). Additionally, surfactants have a clear influence on pharmacokinetics and pharmacodynamics such as sustaining drug release, enhancing the circulation time of vesicles, improving targeting and cellular uptake.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Related URLs:
Date Deposited: 29 Jan 2018 10:58
Last Modified: 04 Sep 2021 10:49
DOI or ID number: 10.1016/j.xphs.2018.01.005
URI: https://researchonline.ljmu.ac.uk/id/eprint/7907
View Item View Item