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Verheggen, RJHM, Eijsvogels, TMH, Catoire, M, Terink, R, Ramakers, R, Bongers, CCWG, Mensink, M, Hermus, ARMM, Thijssen, DHJ and Hopman, MTE (2018) Cytokine responses to repeated, prolonged walking in lean versus overweight/obese individuals. Journal of Science and Medicine in Sport. ISSN 1878-1861
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Cytokine responses to repeated, prolonged walking in lean versus overweight obese individuals..pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (828kB) | Preview |
Abstract
OBJECTIVES: Obesity is characterized by a pro-inflammatory state, which plays a role in the pathogenesis of metabolic and cardiovascular disease. An exercise bout causes a transient increase in pro-inflammatory cytokines, whilst training has anti-inflammatory effects. No previous study examined whether the exercise-induced increase in pro-inflammatory cytokines is altered with repeated prolonged exercise bouts and whether this response differs between lean and overweight/obese individuals. DESIGN: Lean (n=25, BMI 22.9±1.5kg/m2) and age-/sex-matched overweight/obese (n=25; BMI 27.9±2.4kg/m2) individuals performed walking exercise for 30, 40 or 50km per day on four consecutive days (distances similar between groups). METHODS: Circulating cytokines (IL-6, IL-10, TNF-α, IL-1β and IL-8) were examined at baseline and <30min after the finish of each exercise day. RESULTS: At baseline, no differences in circulating cytokines were present between groups. In response to prolonged exercise, all cytokines increased on day 1 (IL-1β: P=0.02; other cytokines: P<0.001). IL-6 remained significantly elevated during the 4 exercise days, when compared to baseline. IL-10, TNF-α, IL-1β and IL-8 returned to baseline values from exercise day 2 (IL-10, IL-1β, IL-8) or exercise day 3 (TNF-α) onward. No significant differences were found between groups for all cytokines, except IL-8 (Time*Group Interaction P=0.02). CONCLUSIONS: These data suggest the presence of early adaptive mechanisms in response to repeated prolonged walking, demonstrated by attenuated exercise-induced elevations in cytokines on consecutive days that occur similar in lean and overweight/obese individuals.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1106 Human Movement And Sports Science, 1117 Public Health And Health Services |
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Elsevier |
| Related URLs: | |
| Date Deposited: | 28 Sep 2018 08:38 |
| Last Modified: | 04 Sep 2021 10:04 |
| DOI or ID number: | 10.1016/j.jsams.2018.07.019 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/9354 |
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