Article

Al Groshi, A, Nahar, L, Ismail, FMD, Evans, AR and Sarker, SD Dichloromethane Extract of the Leaves of Arbutus pavarii Pamp. Exhibits Cytotoxicity Against the Prostate Cancer Cell Line PC3: A Bioassay-guided Isolation and Identification of Arbutin and Betulinic Acid Methyl Ester. Turkish Journal of Pharmaceutical Sciences. ISSN 1304-530X (Accepted)

Alam, MA, Islam, P, Subhan, N, Rahman, MM, Khan, F, Burrows, GE, Nahar, L and Sarker, SD Potential Health Benefits of Anthocyanins in Oxidative Stress Related Disorders. Phytochemistry Reviews. ISSN 1568-7767 (Accepted)

Ball, N, Madden, JC, Paini, A, Mathea, M, Palmer, A, Sperber, S, Hartung, T and van Ravenzwaay, B Key Read Across Framework Components and Biology Based Improvements. Mutation Research. (Accepted)

Banach, M and Penson, P Colchicine and Cardiovascular Outcomes: A Critical Appraisal of Recent Studies. Current Atherosclerosis Reports. ISSN 1523-3804 (Accepted)

Banach, M, Penson, P, Fras, Z, Vrablik, M, Pella, D, Reiner, Z, Nabavi, SM, Sahebkar, A, Kayikcioglu, M, Daccord, M, FH Europe, and International Lipid Expert Panel (ILEP), Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic. Pharmacological Research. ISSN 1043-6618 (Accepted)

Belfield, SJ, Enoch, SJ, Firman, JW, Madden, JC, Schultz, TW and Cronin, MTD Determination of “Fitness-for-Purpose” of Quantitative Structure-Activity Relationship (QSAR) Models to Predict (Eco-)Toxicological Endpoints for Regulatory Use. Regulatory Toxicology and Pharmacology. ISSN 0273-2300 (Accepted)

Bnyan, R, Cesarini, L, Khan, I, Roberts, M and Ehtezazi, T The Effect of Ethanol Evaporation on the Properties of Inkjet Produced Liposomes. DARU : Journal of Pharmaceutical Sciences. ISSN 1560-8115 (Accepted)

Brandt, SD, Carlino, L, Kavanagh, PV, Westphal, F, Dreiseitel, W, Dowling, G, Baumann, MH, Sitte, HH and Halberstadt, AL Syntheses and analytical characterizations of novel (2-aminopropyl)benzo[b]thiophene (APBT) based stimulants. Drug Testing and Analysis. ISSN 1942-7603 (Accepted)

Brandt, SD, Kavanagh, PV, Westphal, F, Dreiseitel, W, Dowling, G, Bowden, MJ and Williamson, JPB Synthetic cannabinoid receptor agonists: analytical profiles and development of QMPSB, QMMSB, QMPCB, 2F-QMPSB, QMiPSB, and SGT-233. Drug Testing and Analysis. ISSN 1942-7603 (Accepted)

Brandt, SD, Kavanagh, PV, Westphal, F, Pulver, B, Morton, K, Stratford, A, Dowling, G and Halberstadt, AL Return of the lysergamides. Part VII: Analytical and behavioural characterization of 1-valeroyl-d-lysergic acid diethylamide (1V-LSD). Drug Testing and Analysis. ISSN 1942-7603 (Accepted)

Brandt, SD, Kavanagh, PV, Westphal, F, Stratford, A, Blanckaert, P, Dowling, G, Grill, M, Schwelm, HM, Auwärter, V and Chapman, SJ Separating the wheat from the chaff: observations on the analysis of lysergamides LSD, MIPLA, and LAMPA. Drug Testing and Analysis. ISSN 1942-7603 (Accepted)

Brandt, SD, Kavanagh, PV, Westphal, F, Stratford, A, Elliott, SP, Dowling, G and Halberstadt, AL Analytical profile of N-ethyl-N-cyclopropyl lysergamide (ECPLA), an isomer of lysergic acid 2,4-dimethylazetidide (LSZ). Drug Testing and Analysis. ISSN 1942-7603 (Accepted)

Brandt, SD, Walters, HM, Partilla, JS, Blough, BE, Kavanagh, PV and Baumann, MH The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats. Psychopharmacology. ISSN 0033-3158 (Accepted)

Bury, D, Alexander-White, C, Clewell, H, Cronin, MTD, Desprez, B, Detroyer, A, Efremenko, A, Firman, JW, Hack, E, Hewitt, NJ, Kenna, G, Klaric, M, Lester, C, Mahoney, C, Ouédraogo, G, Paini, A and Schepky, A New Framework for a Non-Animal Approach Adequately Assures the Safety of Cosmetic Ingredients – A Case Study on Caffeine. Regulatory Toxicology and Pharmacology. ISSN 0273-2300 (Accepted)

Bytyçi, I, Bajraktari, G, Penson, P, Henein, M and Banach, M Efficacy and safety of colchicine in patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. British Journal of Clinical Pharmacology. ISSN 0306-5251 (Accepted)

Ceresa, C, Hutton, S, Lajarin-Cuesta, M, Heaton, R, Hargreaves, IP, Fracchia, L and Diaz De Rienzo, MA Production of Mannosylerythritol Lipids (MELs) to be Used as Antimicrobial Agents against S. aureus ATCC 6538. Current Microbiology. ISSN 0343-8651 (Accepted)

Cronin, K, Bethell, EJ, Jacobson, SL, Egelkamp, C, Hopper, LM and Ross, SR Response Slowing on a simple touchscreen task as an indicator of primate welfare: a study of zoo-housed Japanese macaques. Animal Behavior & Cognition. ISSN 2372-5052 (Accepted)

Cybulska, B, Kłosiewicz-Latoszek, L, Penson, P and Banach, M What Do We Know About the Role of Lipoprotein(a) in Atherogenesis 57 Years After its Discovery? Progress in Cardiovascular Diseases. ISSN 0033-0620 (Accepted)

Drakvik, E, Altenburger, R, Aoki, Y, Backhaus, T, Bahadori, T, Barouki, R, Brack, W, Cronin, MTD, Demeniex, B, Hougaard Bennekou, S, van Klaveren, J, Kneuer, C, Kolossa Gehring, M, Lebret, E, Posthuma, L, Reiber, L, Rider, C, Ruegg, J, Testa, G, van der Burg, B et al, van der Voet, H, Warhurst, AM, van de Water, B, Yamazaki, K, Oberg, M and Bergman, A Statement on Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment. Environment International. ISSN 0160-4120 (Accepted)

Ebbrell, DJ, Madden, JC, Cronin, MTD, Schultz, T and Enoch, SJ Development of a fragment-based in silico profiler for SN2 thiol reactivity and its application in predicting toxicity of chemicals towards Tetrahymena pyriformis. Computational Toxicology. ISSN 2468-1113 (Accepted)

Elliott, S, Holdbrook, T and Brandt, SD Prodrugs of new psychoactive substances (NPS): a new challenge. Journal of Forensic Sciences. ISSN 0022-1198 (Accepted)

Firman, JW, Pestana, CB, Rathman, JF, Vinken, M, Yang, C and Cronin, MTD A robust, mechanistically-based in silico structural profiler for hepatic cholestasis. Chemical Research in Toxicology. ISSN 0893-228X (Accepted)

Firman, JW, Punt, A, Cronin, MTD, Boobis, AR, Wilks, MF, Hepburn, PA, Thief, A and Fussell, KC Exploring the Potential of ToxCast Data in Supporting Read-across for Evaluation of Food Chemical Safety. Chemical Research in Toxicology. ISSN 0893-228X (Accepted)

Gorabi, AM, Penson, P, Banach, M, Motallebnezhad, M, Jamialahmadi, T and Sahebkar, A Epigenetic control of atherosclerosis via DNA methylation: a new therapeutic target? Life Sciences. ISSN 0024-3205 (Accepted)

Grumann, C, Henkel, K, Brandt, SD, Stratford, A, Passie, T and Auwärter, V Pharmacokinetics and subjective effects of 1P-LSD in humans after oral and intravenous administration. Drug Testing and Analysis. ISSN 1942-7603 (Accepted)

Guetchueng, ST, Nahar, L, Ritchie, KJ, Ismail, FMD, Dempster, NM, Nnanga, EN and Sarker, SD Phenolic compounds from the leaves and stem bark of Pseudospondias microcarpa (A. Rich.) Engl. (Anacardiaceae). Biochemical Systematics and Ecology. ISSN 0305-1978 (Accepted)

Halberstadt, AL, Chatha, M, Klein, AK, Wallach, J and Brandt, SD Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology. ISSN 0028-3908 (Accepted)

Hufnagel, A, Fernandez‐Twinn, DS, Blackmore, HL, Ashmore, TJ, Heaton, RA, Jenkins, B, Koulman, A, Hargreaves, IP, Aiken, CE and Ozanne, SE Maternal but not fetoplacental health can be improved by metformin in a murine diet‐induced model of maternal obesity and glucose intolerance. The Journal of Physiology. ISSN 0022-3751 (Accepted)

Ismail, FMD, Nahar, L and Sarker, SD Application of INADEQUATE NMR techniques for directly tracing out the carbon skeleton of a natural product. Phytochemical Analysis. ISSN 0958-0344 (Accepted)

Khalifeh, M, Penson, P, Banach, M and Sahebkar, A Statins as anti-pyroptotic agents. Archives of Medical Science. ISSN 1734-1922 (Accepted)

Khan, KM, Nahar, L, Evans, AR, Ismail, FMD, Dempster, NM, Al-Groshi, A, Zazoianu, AG, Wansi, JD and Sarker, SD Evaluation of cytotoxicity of Trillium govanianum (Melanthiaceae). Phytotherapy Research. ISSN 1099-1573 (Accepted)

Madden, JC, Tan, Y-M, Blaauboer, B and Paini, A Development and Application of Physiologically-Based Kinetic (PBK) Models. Computational Toxicology. ISSN 2468-1113 (Accepted)

Maguire, A, Mooney, C, Flynn, G, Ferguson, Y, O'Keane, V, O'Rourke, D, McMonagle, T, Heaton, R, Phillips, S, Hargreaves, IP, Gill, M and Hargreaves, A No Effect of Coenzyme Q10 on Cognitive Function, Psychological Symptoms, and Health-related Outcomes in Schizophrenia and Schizoaffective Disorder. Journal of Clinical Psychopharmacology. ISSN 0271-0749 (Accepted)

Mahmoud, A, Mullen, R, Penson, P and Morecroft, CW The management of asthma in adult patients in the community pharmacy setting: literature review. Research in Social and Administrative Pharmacy. ISSN 1551-7411 (Accepted)

Mahony, C, Ashton, R, Birk, B, Boobis, A and Cronin, MTD New Ideas for Non-Animal Approaches to Predict Repeated-Dose Systemic Toxicity: Report from an EPAA Blue Sky Workshop. Regulatory Toxicology and Pharmacology. ISSN 0273-2300 (Accepted)

Mellor, CL, Tollefsen, K-E, LaLone, C, Cronin, MTD and Firman, JW In silico identification of chemicals capable of binding to the ecdysone receptor. Environmental Toxicology and Chemistry. ISSN 0730-7268 (Accepted)

Morrison, J, McColl, S, Louhelainen, J, Sheppard, K, May, A, Girdland Flink, EL, Watts, G and Dawnay, N Assessing the performance of quantity and quality metrics using the QIAGEN Investigator® Quantiplex® Pro RGQ kit. Science and Justice. ISSN 1355-0306 (Accepted)

Mustafa, SE, Mustafa, S, Ismail, A, Abas, F, Manap, MYABD, Hamdi, OAA, Elzen, S, Nahar, L and Sarker, SD Impact of Prebiotics on Equol Production from Soymilk Isoflavones by Two Bifidobacteriumspecies. Heliyon. ISSN 2405-8440 (Accepted)

Nahar, L, Onder, A and Sarker, SD A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010-2019). Phytochemical Analysis. ISSN 0958-0344 (Accepted)

Nahar, L and Sarker, SD A Review on Steroid Dimers: 2011-2019. Steroids. ISSN 0039-128X (Accepted)

Nahar, L, Talukdar, AD, Nath, D, Nath, S, Mehan, A, Ismail, FMD and Sarker, SD Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential. Molecules. ISSN 1420-3049 (Accepted)

Nahar, L, Uddin, SJ, Alam, MA and Sarker, SD Extraction of naturally occurring cannabinoids: An update. Phytochemical Analysis. ISSN 0958-0344 (Accepted)

Ogedengbe-Olowofoyeku, AN, Ademola, IO, Wright, CW, Idowu, SO and Fatokun, AA Anthelmintic activity and non-cytotoxicity of phaeophorbide-a isolated from the leaf of Spondias mombin L. Journal of Ethnopharmacology. ISSN 0378-8741 (Accepted)

Ogunrinade, FA, Guetchueng, S, Katola, FO, Aderogba, MA, Akande, IS, Sarker, SD and Olajde, OA Zanthoxylum zanthoxyloides inhibits lipopolysaccharide- and synthetic hemozoin-induced neuroinflammation in BV-2 microglia: roles of NF-B transcription factor and NLRP3 inflammasome activation. Journal of Pharmacy and Pharmacology. ISSN 0022-3573 (Accepted)

Olajide, OA and Sarker, SD Alzheimer’s disease: Natural products as inhibitors of neuroinflammation. Inflammopharmacology. ISSN 0925-4692 (Accepted)

Parsamanesh, N, Karami-Zarandi, M, Banach, M, Penson, PE and Sahebkar, A Effects of statins on myocarditis: A review of underlying molecular mechanisms. Progress in Cardiovascular Diseases. ISSN 0033-0620 (Accepted)

Passie, T, Adams, HA, Logemann, F, Brandt, SD, Wiese, B and Karst, M Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness and neurocognitive performance in healthy volunteers. European Neuropsychopharmacology. ISSN 0924-977X (Accepted)

Penson, P Spotlight Commentary: What’s new in lipid-lowering pharmacology? Integrating basic and clinical research to improve patient outcomes. British Journal of Clinical Pharmacology. ISSN 0306-5251 (Accepted)

Penson, P and Banach, M The role of nutraceuticals in the optimization of lipid-lowering therapy in high-risk patients with dyslipidemia. Current Atherosclerosis Reports. ISSN 1523-3804 (Accepted)

Pestana, C, Firman, JW and Cronin, MTD Incorporating Lines of Evidence from New Approach Methodologies (NAMs) to Reduce Uncertainties in a Category Based Read-Across: A Case Study for Repeated Dose Toxicity. Regulatory Toxicology and Pharmacology. ISSN 0273-2300 (Accepted)

Pletz, J, Allen, T, Madden, JC, Cronin, MTD and Webb, SD A Mechanistic Model to Study the Kinetics and Toxicity of Salicylic Acid in the Kidney of Four Virtual Individuals. Computational Toxicology. ISSN 2468-1113 (Accepted)

Politi, AT, Politis, A and Seton, L Molecular Structure Effects on the Aggregation Motif of Porphyrins: Computational Insights. Advanced Theory and Simulation. ISSN 2513-0390 (Accepted)

Radapong, S, Sarker, SD and Ritchie, KJ Oxyresveratrol possesses DNA damaging activity. Molecules. ISSN 1420-3049 (Accepted)

Ritchie, L, Qin, S, Penson, P, Henney, N and Lip, G Vernakalant hydrochloride for the treatment of atrial fibrillation: An evaluation of its place in clinical practice. Future Cardiology. ISSN 1479-6678 (Accepted)

Rivera Quiroga, R, Cardona, N, Padilla, L, Rivera, W, Rocha Roa, C, Diaz, M, Morales, S and Martinez, M In silico selection and in vitro evaluation of new molecules that inhibit the adhesion of Streptococcus mutans through Antigen I/II. International Journal of Molecular Sciences. ISSN 1422-0067 (Accepted)

Rogiers, V, Benfenati, E, Bernauer, U, Bodin, L and Cronin, MTD The way forward for assessing the human health safety of cosmetics in the EU - Workshop Proceedings. Toxicology. ISSN 0300-483X (Accepted)

Ruiz, AJ, Tibary, A, Heaton, R, Hargreaves, IP, Leadon, DP and Bayly, WM Effects of Feeding Coenzyme Q10-Ubiquinol on Plasma Coenzyme Q10 Concentrations and Semen Quality in Stallions. Journal of Equine Veterinary Science. ISSN 0737-0806 (Accepted)

Sapounidou, M, Ebbrell, DJ, Bonnell, M, Campos, B, Firman, J, Gitsell, S and Cronin, MTD Development of an Enhanced Mechanistically-Driven Mode of Action Classification Scheme for Adverse Effects in Environmental Species. Environmental Science and Technology. ISSN 0013-936X (Accepted)

Sarfraz, A, Javeed, M, Shah, MA, Hussain, G, Shafiq, N, Sarfraz, I, Riaz, A, Sadiqa, A, Zara, R, Zafar, S, Kanwal, L, Sarker, SD and Rasul, A Biochanin A: A Novel Bioactive Multifunctional Compound from Nature. Science of the Total Environment. ISSN 0048-9697 (Accepted)

Sarfraz, I, Rasul, A, Hussain, G, Shah, MA, Zahoor, FA, Asrar, M, Selamoglu, Z, Ji, X-Y, Adem, S and Sarker, SD 6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: from cancer initiation to metastasis and chemoresistance. BioFactors. ISSN 0951-6433 (Accepted)

Seukep, AJ, Kuete, V, Nahar, L, Sarker, SD and Guo, M Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification. Journal of Pharmaceutical Analysis. ISSN 2095-1779 (Accepted)

Spinu, N, Cronin, MTD, Enoch, SJ, Madden, JC and Worth, A Quantitative Adverse Outcome Pathway (qAOP) models for toxicity prediction. Archives of Toxicology. ISSN 0340-5761 (Accepted)

Spinu, N, Cronin, MTD, Lao, J, Bal-Price, A, Campia, I, Enoch, SJ, Madden, JC, Lagares, LM, Novič, M, Pamies, D, Scholz, S, Villeneuve, DL and Worth, A Probabilistic Modelling of Developmental Neurotoxicity based on a Simplified Adverse Outcome Pathway Network. Computational Toxicology. ISSN 2468-1113 (Accepted)

Spinu, N, Cronin, MTD, Madden, JC and Worth, A A Matter of Trust: Learning Lessons About Causality Will Make qAOPs Credible. Computational Toxicology. ISSN 2468-1113 (Accepted)

Stepien, KM, Roncaroli, F, Turton, N, Hendriksz, CJ, Roberts, M, Heaton, R and Hargreaves, IP Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review. Journal of Clinical Medicine. ISSN 2077-0383 (Accepted)

Thompson, C, Firman, JW, Goldsmith, M, Grulke, C, Tan, Y-M, Paini, A, Penson, P, Sayre, R, Webb, S and Madden, JC A systematic review of published physiologically-based kinetic models and an assessment of their chemical space coverage. Alternatives to Laboratory Animals. ISSN 0261-1929 (Accepted)

Wright, S, Morecroft, CW, Mullen, R and Ewing, AB UK hospital patient discharge: the patient perspective. European Journal of Hospital Pharmacy. ISSN 2047-9956 (Accepted)

Wu, L, Georgiev, MI, Cao, H, Nahar, L, El-Seedi, HR, Sarker, SD, Xiao, J and Lu, B Therapeutic potential pf phenylethanoid glycosides: A systematic review. Medicinal Research Reviews. ISSN 0198-6325 (Accepted)

Yang, C, Cronin, MTD, Arvidson, K, Bienfait, B, Enoch, SJ, Heldreth, B, Hobocienski, B, Muldoon-Jacobs, K, Lan, Y, Madden, JC, Magdziarz, T, Marusczyk, J, Mostrag, A, Nelms, MD, Przybylak, KR, Rathman, JF, Richarz, A-N, Richard, AM, Ribeiro, JV, Sacher, O et al, Schwab, C, Vitcheva, P, Volarath, P and Worth, AP COSMOS Next Generation – a public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals. Computational Toxicology. ISSN 2468-1113 (Accepted)

Yaqoob, N, Bloch, KM, Evans, AR and Lock, E The effect of Trichloroethylene metabolites on the hepatic vitamin B12-dependent methionine-salvage pathway and its relevance to increased excretion of formic aciduria in the rat. Toxicological Research. ISSN 1976-8257 (Accepted)

Conference or Workshop Item

Islam, Y, Leach, AG, Coxon, CR, Downing, J, Platt, M, Pluchino, S and Ehtezazi, T Smart micellar systems for brain drug delivery. In: KTN Biopharmaceutical Formulation Group, 11 July 2017 - 11 July 2017, Mancheter. (Accepted)

Lambertsen, R, Tang, SOT, Davies, J and Morecroft, CW Development of A “PharmaComm” Serious Game for Teaching Pharmacist Communication and Drug Administration in a Virtual Hospital Setting. In: 9th International Conference on Developments in e-Systems Engineering (DESE2016), 31 August 2016 - 02 September 2016, Liverpool & Leeds. (Unpublished)