Ross, K (2021) MiR equal than others: MicroRNA enhancement for cutaneous wound healing. Journal of Cellular Physiology. ISSN 0021-9541

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Abstract

Keratinocyte migration is vital in the re-epithelialisation of the skin during wound healing. Multiple factors conspire to impair closure of chronic wounds such as diabetic foot ulcers, venous leg ulcers and pressure wounds. Despite deep mechanistic understanding of microRNA (miRNA) biogenesis and function, the translational potential of these small genetic molecules has not been exploited to promote wound repair. In this review, I focus on miRNAs whose importance for wound healing stems from their impact on epidermal keratinocyte behaviour. These include miR-21-5p, miR-31-5p, miR-132-3p, miR-19b, miR-20a, miR-184, miR-129-5p and miR-335-5p which regulate diverse aspect of keratinocyte biology such as migration, proliferation, differentiation, inflammation and wound closure. A combinatorial approach where two or more miRNA mimics targeting distinct but complementary wound healing processes is proposed as this may enhance wound repair more effectively than any single miRNA mimic alone.

Item Type:	Article
Uncontrolled Keywords:	0601 Biochemistry and Cell Biology, 1116 Medical Physiology
Subjects:	R Medicine > RL Dermatology R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Wiley
Date Deposited:	12 Jul 2021 10:29
Last Modified:	04 Sep 2021 05:19
DOI or ID number:	10.1002/jcp.30485
URI:	https://researchonline.ljmu.ac.uk/id/eprint/15173

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