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Kirwan, R, Isanejad, M, Davies, IG and Mazidi, M (2021) Genetically Determined Serum 25-Hydroxyvitamin D Is Associated with Total, Trunk, and Arm Fat-Free Mass: A Mendelian Randomization Study. Journal of Nutrition, Health and Aging. ISSN 1279-7707
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Abstract
Purpose: Low serum vitamin D status has been associated with reduced muscle mass in observational studies although the relationship is controversial and a causal association cannot be determined from such observations. Two-sample Mendelian randomization (MR) was applied to assess the association between serum vitamin D (25(OH)D) and total, trunk, arm and leg fat-free mass (FFM).
Methods: MR was implemented using summary-level data from the largest genome-wide association studies (GWAS) on vitamin D (n=73,699) and total, trunk, arm and leg FFM. Inverse variance weighted method (IVW) was used to estimate the causal estimates. Weighted median (WM)-based method, and MR-Egger, leave-one-out were applied as sensitivity analysis.
Results: Genetically higher serum 25(OH)D levels had a positive effect on total (IVW = Beta: 0.042, p = 0.038), trunk (IVW = Beta: 0.045, p = 0.023) and arm (right arm IVW = Beta: 0.044, p = 0.002; left arm IVW = Beta: 0.05, p = 0.005) FFM. However, the association with leg FFM was not significant (right leg IVW = Beta: 0.03, p = 0.238; left leg IVW = Beta: 0.039, p = 0.100). The likelihood of heterogeneity and pleiotropy was determined to be low (statistically non-significant), and the observed associations were not driven by single SNPs. Furthermore, MR pleiotropy residual sum and outlier test did not highlight any outliers.
Conclusions: Our results illustrate the potentially causal, positive effect of serum 25(OH)D concentration on total, trunk and upper body appendicular fat-free mass.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1103 Clinical Sciences, 1111 Nutrition and Dietetics |
| Subjects: | Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Biological & Environmental Sciences (from Sep 19) Sport & Exercise Sciences |
| Publisher: | Springer Verlag |
| Date Deposited: | 16 Nov 2021 09:56 |
| Last Modified: | 16 Nov 2021 10:00 |
| DOI or ID number: | 10.1007/s12603-021-1696-1 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/15786 |
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