Alsaffar, MM, Hasan, M, McStay, GP and Sedky, M (2022) Digital DNA lifecycle security and privacy: An overview. Briefings in Bioinformatics, 23 (2). ISSN 1467-5463

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Abstract

DNA sequencing technologies have advanced significantly in the last few years leading to advancements in biomedical research which has improved personalised medicine and the discovery of new treatments for diseases. Sequencing technology advancement has also reduced the cost of DNA sequencing, which has led to the rise of direct-to-consumer (DTC) sequencing, e.g. 23andme.com, ancestry.co.uk, etc. In the meantime, concerns have emerged over privacy and security in collecting, handling, analysing and sharing DNA and genomic data. DNA data are unique and can be used to identify individuals. Moreover, those data provide information on people's current disease status and disposition, e.g. mental health or susceptibility for developing cancer. DNA privacy violation does not only affect the owner but also affects their close consanguinity due to its hereditary nature. This article introduces and defines the term 'digital DNA life cycle' and presents an overview of privacy and security threats and their mitigation techniques for predigital DNA and throughout the digital DNA life cycle. It covers DNA sequencing hardware, software and DNA sequence pipeline in addition to common privacy attacks and their countermeasures when DNA digital data are stored, queried or shared. Likewise, the article examines DTC genomic sequencing privacy and security.

Item Type:	Article
Additional Information:	This is a pre-copyedited, author-produced version of an article accepted for publication in Briefings in Bioinformatics following peer review. The version of record Muhalb M Alsaffar, Mohammad Hasan, Gavin P McStay, Mohamed Sedky, Digital DNA lifecycle security and privacy: an overview, Briefings in Bioinformatics, Volume 23, Issue 2, March 2022, bbab607 is available online at: https://doi.org/10.1093/bib/bbab607
Uncontrolled Keywords:	Animals; Humans; DNA; Genomics; Life Cycle Stages; Genome; Privacy; DNA attack; DNA privacy; DNA security; digital DNA attacks; digital DNA life cycle; direct-to-consumer (DTC) security; genomic attacks; genomic privacy; genomic privacy-preserving techniques; genomic security; re-creational genomic security; Animals; DNA; Genome; Genomics; Humans; Life Cycle Stages; Privacy; Bioinformatics; 0601 Biochemistry and Cell Biology; 0802 Computation Theory and Mathematics; 0899 Other Information and Computing Sciences
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Oxford University Press (OUP)
SWORD Depositor:	A Symplectic
Date Deposited:	24 Jun 2022 09:51
Last Modified:	31 Jan 2023 00:50
DOI or ID number:	10.1093/bib/bbab607
URI:	https://researchonline.ljmu.ac.uk/id/eprint/17149

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