Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Dietary phytochemical consumption is inversely associated with liver alkaline phosphatase in Middle Eastern adults

Darabi, Z, Webb, RJ, Mozaffari-Khosravi, H, Mirzaei, M, Davies, IG, Khayyatzadeh, SS and Mazidi, M (2022) Dietary phytochemical consumption is inversely associated with liver alkaline phosphatase in Middle Eastern adults. World Journal of Hepatology, 14 (5). pp. 1006-1015. ISSN 1948-5182

WJH-14-1006.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (508kB) | Preview


BACKGROUND The hepatoprotective effects of phytochemicals are controversial. A dietary phytochemical index (DPI) has been suggested as an alternative method for quantifying the phytochemical content of foods. AIM To assess the DPI in relation to liver function tests among a representative sample of Iranian adults. METHODS A total of 5111 participants aged 35-70 years old were included in this cross-sectional study by a multistage cluster random sampling method. Dietary intakes were collected by a validated and reliable food frequency questionnaire with 121 items. DPI was calculated by the percent of daily energy intake taken from phytochemical-rich foods. Fasting serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) were determined. Linear regression was used to investigate the association between DPI and levels of liver enzymes using crude and adjusted models. RESULTS There was an inverse association between DPI score and serum ALP in the crude model (β = -0.05; P< 0.001). This association remained significant after adjustment for body mass index, age, smoking, energy intake, history of diabetes, and education (β = -0.03; P= 0.01). No significant associations were found between DPI score and serum levels of AST, ALT, and GGT. The individuals with the highest DPI scores consumed significantly higher amounts of fruits, vegetables, legumes, nuts, and cereals, yet were shown to have significantly higher serum total cholesterol and low-density lipoprotein cholesterol, as well as several other metabolic abnormalities. CONCLUSION Higher adherence to phytochemical-rich foods was associated with lower levels of ALP, but no change in other liver enzymes. Those with higher DPI scores also consumed food items associated with a healthier overall dietary pattern; however, they also presented several unexpected metabolic derangements. Additional randomised trials are needed to better determine the effects of phytochemical-rich foods on liver function.

Item Type: Article
Subjects: T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Baishideng Publishing Group Inc.
SWORD Depositor: A Symplectic
Date Deposited: 09 Aug 2022 09:45
Last Modified: 09 Aug 2022 09:45
DOI or ID number: 10.4254/wjh.v14.i5.1006
URI: https://researchonline.ljmu.ac.uk/id/eprint/17357
View Item View Item