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Kirwan, R (2022) Differential effects of vitamin D on upper and lower body fat-free mass: potential mechanisms. Molecular Biology Reports. ISSN 0301-4851
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Differential effects of vitamin D on upper and lower body fat-free mass potential mechanisms.pdf - Published Version Available under License Creative Commons Attribution. Download (962kB) | Preview |
Abstract
Vitamin D insufficiency is a global health concern and low vitamin D status is regularly associated with reduced muscle mass and sarcopenia in observational research. Recent research using Mendelian randomization (MR) has highlighted the potentially causal positive effect of serum vitamin D (25(OH)D) on total, trunk and upper body appendicular fat-free mass (FFM). However, no such effect was found in lower body FFM, a result that mirrors the outcomes of some vitamin D intervention studies. Here we review the current literature on vitamin D, muscle mass and strength and discuss some potential mechanisms for the differing effects of vitamin D on upper and lower body FFM. In particular, differences in distribution of the vitamin D receptor as well as androgen receptors, in the upper and lower body musculature, will be discussed.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0601 Biochemistry and Cell Biology; Biochemistry & Molecular Biology |
| Subjects: | G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > QH Natural history > QH301 Biology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Biological & Environmental Sciences (from Sep 19) |
| Publisher: | Springer Science and Business Media LLC |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 01 Dec 2022 12:04 |
| Last Modified: | 01 Dec 2022 12:04 |
| DOI or ID number: | 10.1007/s11033-022-07998-7 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18186 |
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