Prone-Olazabal, D, Davies, I and González-Galarza, FF (2023) Metabolic Syndrome: An Overview on Its Genetic Associations and Gene-Diet Interactions. Metabolic syndrome and related disorders, 21 (10). pp. 545-560. ISSN 1540-4196

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Abstract

Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias and whose inter-related occurrence may increase the odds of developing type 2 diabetes and cardiovascular diseases. MetS has become one of the most studied conditions, nevertheless, due to its complex etiology, this has not been fully elucidated. Recent evidence describes that both genetic and environmental factors play an important role on its development. With the advent of genomic-wide association studies, single nucleotide polymorphisms (SNPs) have gained special importance. In this review, we present an update of the genetics surrounding MetS as a single entity as well as its corresponding risk factors, considering SNPs and gene-diet interactions related to cardiometabolic markers. In this study, we focus on the conceptual aspects, diagnostic criteria, as well as the role of genetics, particularly on SNPs and polygenic risk scores (PRS) for interindividual analysis. In addition, this review highlights future perspectives of personalized nutrition with regard to the approach of MetS and how individualized multiomics approaches could improve the current outlook.

Item Type:	Article
Additional Information:	This is the accepted version of the following article: Metabolic Syndrome: An Overview on Its Genetic Associations and Gene–Diet Interactions Denisse Prone-Olazabal, Ian Davies, and Faviel Francisco González-Galarza Metabolic Syndrome and Related Disorders 2023 21:10, 545-560, which has now been formally published in final form at Metabolic syndrome and related disorders at 10.1089/met.2023.0125. This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ self-archiving terms and conditions.
Uncontrolled Keywords:	Humans; Diabetes Mellitus, Type 2; Obesity; Diet; Risk Factors; Polymorphism, Single Nucleotide; Metabolic Syndrome; genetic associations; gene–diet interaction; metabolic syndrome; polygenic risk scores; polymorphisms; Humans; Metabolic Syndrome; Diabetes Mellitus, Type 2; Obesity; Diet; Risk Factors; Polymorphism, Single Nucleotide; 1004 Medical Biotechnology; 1103 Clinical Sciences; 1117 Public Health and Health Services; Endocrinology & Metabolism
Subjects:	T Technology > TX Home economics > TX341 Nutrition. Foods and food supply Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport & Exercise Sciences
Publisher:	Mary Ann Liebert Inc
SWORD Depositor:	A Symplectic
Date Deposited:	19 Jan 2024 13:41
Last Modified:	19 Jan 2024 13:45
DOI or ID number:	10.1089/met.2023.0125
URI:	https://researchonline.ljmu.ac.uk/id/eprint/22370

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