Tools
Tools
Wang, R, Liu, Y, Thabane, L, Olier, I, Li, L, Ortega-Martorell, S, Lip, GYH and Li, G (2024) Relationship between trajectories of dietary iron intake and risk of type 2 diabetes mellitus: evidence from a prospective cohort study. Nutrition Journal, 23 (1). p. 15.
|
Text
s12937-024-00925-5.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
|
|
Text
12937_2024_925_MOESM1_ESM.pdf - Supplemental Material Available under License Creative Commons Attribution. Download (103kB) | Preview |
Abstract
Background: The association between dietary iron intake and the risk of type 2 diabetes mellitus (T2DM) remains inconsistent. In this study, we aimed to investigate the relationship between trajectories of dietary iron intake and risk of T2DM. Methods: This study comprised a total of 61,115 participants without a prior T2DM from the UK Biobank database. We used the group-based trajectory model (GBTM) to identify different dietary iron intake trajectories. Cox proportional hazards models were used to evaluate the relationship between trajectories of dietary iron intake and risk of T2DM. Results: During a mean follow-up of 4.8 years, a total of 677 T2DM events were observed. Four trajectory groups of dietary iron intake were characterized by the GBTM: trajectory group 1 (with a mean dietary iron intake of 10.9 mg/day), 2 (12.3 mg/day), 3 (14.1 mg/day) and 4 (17.6 mg/day). Trajectory group 3 was significantly associated with a 38% decreased risk of T2DM when compared with trajectory group 1 (hazard ratio [HR] = 0.62, 95% confidence interval [CI]: 0.49–0.79), while group 4 was significantly related with a 30% risk reduction (HR = 0.70, 95% CI: 0.54–0.91). Significant effect modifications by obesity (p = 0.04) and history of cardiovascular disease (p < 0.01) were found to the relationship between trajectories of dietary iron intake and the risk of T2DM. Conclusions: We found that trajectories of dietary iron intake were significantly associated with the risk of T2DM, where the lowest T2DM risk was observed in trajectory group 3 with a mean iron intake of 14.1 mg/day. These findings may highlight the importance of adequate dietary iron intake to the T2DM prevention from a public health perspective. Further studies to assess the relationship between dietary iron intake and risk of T2DM are needed, as well as intervention studies to mitigate the risks of T2DM associated with dietary iron changes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Dietary iron intake; Trajectory; Type 2 diabetes mellitus; 1111 Nutrition and Dietetics; Nutrition & Dietetics |
| Subjects: | T Technology > TX Home economics > TX341 Nutrition. Foods and food supply R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Computer Science & Mathematics Nursing & Allied Health |
| Publisher: | BioMed |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 14 Feb 2024 11:59 |
| Last Modified: | 14 Feb 2024 12:00 |
| DOI or ID number: | 10.1186/s12937-024-00925-5 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/22616 |
 |
View Item |