Leońska-Duniec, A, Jastrzębski, Z, Jażdżewska, A, Moska, W, Lulińska-Kuklik, E, Sawczuk, M, Gubaydullina, SI, Shakirova, AT, Cięszczyk, P, Maszczyk, A and Ahmetov, II (2018) Individual responsiveness to exercise-induced fat loss and improvement of metabolic profile in young women is associated with polymorphisms of adrenergic receptor genes. Journal of Sports Science and Medicine, 17 (1). pp. 134-144. ISSN 1303-2968

Preview

Text INDIVIDUAL RESPONSIVENESS TO EXERCISE-INDUCED FAT LOSS AND IMPROVEMENT OF METABOLIC PROFILE IN YOUNG WOMEN IS ASSOCIATED WITH POLYMORPHISMS OF ADRENERGIC RECEPTOR GENES.pdf - Accepted Version Download (655kB) | Preview

Abstract

The effectiveness of physical exercise on fat loss and improvement of aerobic capacity varies considerably between individuals. A strong linkage exists between common allelic variants of the adrenergic receptor genes and weight gain, as well as changes in body composition. Therefore we aimed to check if body composition and metabolic variables were modulated by the ADRB2 (Gly16Arg and Glu27Gln), ADRB3 (Trp64Arg) and ADRA2A (rs553668 G/A) gene polymorphisms in 163 Polish sedentary women (age 19-24; body mass index (BMI) 21.7 ± 0.2 kg·m-2) involved in a 12-week aerobic training program. Only 74.8% of participants lost fat mass. On average, participants lost 5.8 (10.4)% of their relative fat mass with training (range: +28.3 to -63.6%). The improvement of VO2maxwas significantly greater in women who could lose their fat mass compared to women who were unsuccessful in fat loss (4.5 (5.6)% vs. 1.5 (3.8)%; p = 0.0045). The carriers of a low number (0-3) of obesity-related risk alleles (ADRB2 Gly16, ADRB2 Glu27, ADRA2A rs553668 G) were more successful in fat mass loss compared to the carriers of a high number (5-6) of risk alleles (7.7 (9.8) vs 4.0 (9.4)%, p = 0.0362). The presented results support the assumption that variation within adrenergic receptor genes contributes to interindivid-ual changes of body composition in response to physical exercise.

Item Type:	Article
Uncontrolled Keywords:	Science & Technology; Life Sciences & Biomedicine; Sport Sciences; ADRB2; ADRB3; ADRA2A; polygenic; obesity; fat; HDL; HUMAN BETA(2)-ADRENERGIC RECEPTOR; OBESITY-RELATED PHENOTYPES; BLOOD-PRESSURE ELEVATION; BETA(3)-ADRENERGIC RECEPTOR; TRP64ARG MUTATION; PHYSICAL-ACTIVITY; BODY-COMPOSITION; ADIPOSE-TISSUE; WEIGHT-GAIN; ATHLETIC PERFORMANCE; ADRB2; ADRB3; ADRA2A; polygenic; obesity; fat; HDL; ADRA2A; ADRB2; ADRB3; HDL; fat; obesity; polygenic; 32 Biomedical and Clinical Sciences; 42 Health Sciences; 4207 Sports Science and Exercise; Clinical Research; Prevention; Genetics; Physical Activity; Nutrition; Obesity; 2.1 Biological and endogenous factors; Metabolic and endocrine; Cancer; 0913 Mechanical Engineering; 1106 Human Movement and Sports Sciences; 1701 Psychology; Sport Sciences; 3202 Clinical sciences; 4207 Sports science and exercise; 5201 Applied and developmental psychology
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	Journal of Sports Science and Medicine
Related URLs:	https://www.jssm.org/index.php
SWORD Depositor:	A Symplectic
Date Deposited:	09 Apr 2025 08:34
Last Modified:	09 Apr 2025 08:34
URI:	https://researchonline.ljmu.ac.uk/id/eprint/26133

View Item