Phytochemical Nanoparticles for the Treatment of Neurological Disorders

Ehtezazi, T ORCID: 0000-0002-1576-2396 and Sarker, SD ORCID: 0000-0003-4038-0514 (2025) Phytochemical Nanoparticles for the Treatment of Neurological Disorders. Phytochemical Analysis. ISSN 0958-0344

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Abstract

Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position. The treatment of neurological disorders is challenging because of the complex nature of the disease, as well as limited accessibility to this target organ due to several biological barriers. There is a wide range of treatment options for neurological disorders. Small drug molecules, antibodies, and stem cells have been employed for the treatment of neurodegenerative diseases such as AD, but currently, there is no effective treatment for AD. As conventional drugs have not been successful in achieving therapeutic outcomes, natural products such as curcumin, stemming from traditional medicines, have been tested for the treatment of neurodegenerative diseases such as AD. However, this compound has not shown significant therapeutic effects for the treatment of brain diseases, mainly due to rapid clearance from the body. Therefore, phytochemical nanoparticles have been developed. In this review article, the rationale has been provided for the use of nanoparticles for the treatment of neurodegenerative diseases with emphasis on phytochemical nanoparticles.

Item Type:	Article
Uncontrolled Keywords:	03 Chemical Sciences; 06 Biological Sciences; 11 Medical and Health Sciences; Analytical Chemistry; 3108 Plant biology
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Wiley
Date of acceptance:	18 July 2025
Date of first compliant Open Access:	31 July 2025
Date Deposited:	31 Jul 2025 09:29
Last Modified:	31 Jul 2025 09:45
DOI or ID number:	10.1002/pca.70020
URI:	https://researchonline.ljmu.ac.uk/id/eprint/26873

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