Formulation and Delivery of Mitragynine: A Mini Review

Sarker, S ORCID: 0000-0003-4038-0514 and Nahar, L (2025) Formulation and Delivery of Mitragynine: A Mini Review. Journal of Medicinal Natural Products, 2 (3).

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Abstract

Mitragynine is the most abundant psychoactive indole alkaloid found in the leaves of Mitragyna speciosa, which is commonly known as “Kratom”, and is distributed widely in Indonesia, Malaysia, Papua New Guinea, the Philippines, and Thailand. The leaves of M. speciosa are prepared for oral consumption and typically involve dried leaves that are brewed into tea or ground and placed into capsules. Additionally, M. speciosa is also used as a leaf poultice to treat fever, diarrhoea and for wound healing. In addition to peroral delivery, mitragynine could also be delivered through nasal and transdermal routes. The application of nanotechnology has been found to enhance the delivery of mitragynine and thus to enhance its therapeutic efficacy. This mini review, for the first time, presents a critical appraisal of the available literature on the formulation and delivery of mitragynine.

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Scilight Press Pty Ltd
Date of acceptance:	22 September 2025
Date of first compliant Open Access:	24 September 2025
Date Deposited:	24 Sep 2025 11:06
Last Modified:	24 Sep 2025 11:15
DOI or ID number:	10.53941/jmnp.2025.100020
URI:	https://researchonline.ljmu.ac.uk/id/eprint/27197

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