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Mantle, D, Cufflin, N, Purcell, T and Hargreaves, I 
ORCID: 0000-0002-2760-5603
(2025)
Ischaemia–Reperfusion Injury in Organ Transplantation: Role of Coenzyme Q10.
Journal of Clinical Medicine, 14 (18).
pp. 1-15.
ISSN 2077-0383
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Abstract
The success of organ transplantation can be compromised by ischaemia-reperfusion injury (IRI), an unavoidable consequence of transplant surgery. IRI is associated with mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis/ferroptosis. There is therefore a rationale for supplementation with coenzyme Q10 (CoQ10) to mediate the adverse effects of IRI, given the role of CoQ10 in promoting normal mitochondrial function, as an antioxidant, and as an anti-inflammatory and anti-apoptotic/ferroptotic agent. In this article we have reviewed the potential role of supplementary CoQ10 in organ transplantation in preclinical animal studies based on the above actions; the role of supplementary CoQ10 in promoting stem cell action in transplantation and its role in alleviating the adverse effects of immunosuppressants used in organ transplantation are also discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | apoptosis; coenzyme Q10; ferroptosis; immunosuppressants; inflammation; mitochondrial dysfunction; organ transplantation; oxidative stress; stem cells; 3206 Medical Biotechnology; 32 Biomedical and Clinical Sciences; Organ Transplantation; Transplantation; Dietary Supplements; Nutrition; Complementary and Integrative Health; 2.1 Biological and endogenous factors; 5.1 Pharmaceuticals; 1103 Clinical Sciences; 32 Biomedical and clinical sciences |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | MDPI |
| Date of acceptance: | 10 September 2025 |
| Date of first compliant Open Access: | 1 October 2025 |
| Date Deposited: | 01 Oct 2025 13:27 |
| Last Modified: | 01 Oct 2025 13:30 |
| DOI or ID number: | 10.3390/jcm14186486 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/27238 |
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