Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Sesquiterpenes and lignans from the flower buds of Daphne genkwa and their nitric oxide inhibitory activities.

Zhang, C-Y, Luo, L, Xia, J, Song, Y-N, Zhang, L-J, Zhang, M, Rahman, K, Ye, Y, Zhang, H and Zhu, J-Y (2017) Sesquiterpenes and lignans from the flower buds of Daphne genkwa and their nitric oxide inhibitory activities. Natural Product Research. ISSN 1478-6419

[img]
Preview
Text
Sesquiterpenes and lignans from the flower buds of Daphne genkwa and their nitric oxide inhibitory activities..pdf - Accepted Version

Download (343kB) | Preview
Figure 1
Preview
Image (Figure 1)
Figure[1].pdf - Supplemental Material

Download (193kB) | Preview
[img]
Preview
Image
GraphicalAbstract.jpg - Supplemental Material

Download (1MB) | Preview
[img]
Preview
Text
Supplementary Material[1].pdf - Supplemental Material

Download (3MB) | Preview
[img]
Preview
Text
Table[1].pdf - Supplemental Material

Download (110kB) | Preview

Abstract

Chemical investigation of the Daphne genkwa has led to the isolation of four sesquiterpenes (1a/1b, 2 and 3), including one pair of sesquiterpene enantiomers (1a/1b), 1a is a new compound (+)-4-hydroxy-10-epirotundone, and twelve lignans (4-15). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1a/1b were determined by CD analysis. All compounds were examined for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in BV-2 microglial cells, and compounds 7-10 exhibited pronounced inhibition on NO production with IC50 values in the range of 5.8-10.2 μM, being more active than the positive control, quercetin (IC50 = 17.0 μM).

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Natural Product Research on 20th October 2017, available online: http://www.tandfonline.com/10.1080/14786419.2017.1389937
Uncontrolled Keywords: MD Multidisciplinary
Subjects: Q Science > QK Botany
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Related URLs:
Date Deposited: 08 Nov 2017 10:03
Last Modified: 04 Sep 2021 03:39
DOI or ID number: 10.1080/14786419.2017.1389937
URI: https://researchonline.ljmu.ac.uk/id/eprint/7483
View Item View Item