Article

Maasar, M-F, Turner, DC, Gorski, PP, Seaborne, RA, Strauss, JA, Shepherd, SO, Cocks, MS, Pillon, NJ, Zierath, JR, Hulton, AT, Drust, B and Sharples, AP (2021) The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle. Frontiers in Physiology, 12. ISSN 1664-042X

Turner, DC, Gorski, PP, Seaborne, RA, Viggars, M, Murphy, M, Jarvis, JC, Martin, NRW, Stewart, CE and Sharples, AP (2021) Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo. Journal of Cellular Physiology. ISSN 1097-4652

Hughes, D, Turner, DC, Baehr, LM, Seaborne, RA, Viggars, M, Jarvis, JC, Gorski, P, Stewart, CE, Owens, DJ, Bodine, S and Sharples, AP (2021) Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism. American Journal of Physiology: Cell Physiology, 320 (1). C45-C56. ISSN 0363-6143

Turner, DC, Gorski, PP, Maasar, MF, Seaborne, RA, Baumert, P, Brown, AD, Kitchen, MO, Erskine, RM, Dos-Remedios, I, Voisin, S, Eynon, N, Sultanov, RI, Borisov, OV, Larin, AK, Semenova, EA, Popov, DV, Generozov, EV, Stewart, CE, Drust, B, Owens, DJ et al, Ahmetov, II and Sharples, AP (2020) DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity. Scientific Reports, 10 (1). ISSN 2045-2322

Turner, DC, Gorski, PP, Maasar, MF, Seaborne, RA, Baumert, P, Brown, AD, Kitchen, MO, Erskine, RM, Dos-Remedios, I, Voisin, S, Eynon, N, Sultanov, RI, Borisov, OV, Larin, AK, Semenova, EA, Popov, DV, Generozov, EV, Stewart, CE, Drust, B, Owens, DJ et al, Ahmetov, II and Sharples, AP (2020) DNA methylation across the genome in aged human skeletal muscle tissue and stem cells: The role of HOX genes and physical activity. Scientific Reports, 10.

Hearris, MA, Owens, DJ, Strauss, JA, Shepherd, SO, Sharples, AP, Morton, JP and Louis, JB (2020) Graded reductions in pre-exercise glycogen concentration do not augment exercise-induced nuclear AMPK and PGC-1α protein content in human muscle. Experimental Physiology, 105 (11). pp. 1882-1894. ISSN 1469-445X

Allan, R, Morton, JP, Close, GL, Drust, B, Gregson, W and Sharples, AP (2020) PGC-1 alpha alternative promoter (Exon 1b) controls augmentation of total PGC-1 alpha gene expression in response to cold water immersion and low glycogen availability. European Journal of Applied Physiology, 120 (11). pp. 2487-2493. ISSN 1439-6319

Voisin, S, Harvey, NR, Haupt, LM, Griffiths, LR, Ashton, KJ, Coffey, VG, Doering, TM, Thompson, J-LM, Benedict, C, Cedernaes, J, Lindholm, ME, Craig, JM, Rowlands, DS, Sharples, AP, Horvath, S and Eynon, N (2020) An epigenetic clock for human skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle. ISSN 2190-5991

Hammond, KM, Sale, C, Fraser, W, Tang, J, Shepherd, SO, Strauss, JA, Close, GL, Cocks, MS, Louis, J, Pugh, JN, Stewart, CE, Sharples, AP and Morton, JP (2019) Post-exercise carbohydrate and energy availability induce independent effects on skeletal muscle cell signalling and bone turnover: implications for training adaptation. The Journal of Physiology, 597 (18). pp. 4779-4796. ISSN 0022-3751

Allan, R, Sharples, AP, Cocks, MS, Drust, B, Dutton, J, Dugdale, HF, Mawhinney, C, Clucas, A, Hawkins, W, Morton, JP and Gregson, W (2019) Low pre-exercise muscle glycogen availability offsets the effect of post exercise cold water immersion in augmenting PGC-1α gene expression. Physiological Reports. ISSN 2051-817X

Hearris, MA, Hammond, KM, Seaborne, RA, Stocks, B, Shepherd, SO, Philp, A, Sharples, AP, Morton, JP and Louis, JB (2019) Graded reductions in pre-exercise muscle glycogen impair exercise capacity but do not augment cell skeletal muscle signalling: implication for CHO periodisation. Journal of Applied Physiology. ISSN 8750-7587

Seaborne, RA, Hughes, DC, Turner, DC, Owens, DJ, Baehr, LM, Gorski, P, Semenova, EA, Borisov, OV, Larin, AK, Popov, DV, Generozov, EV, Sutherland, H, Ahmetov, II, Jarvis, JC, Bodine, SC and Sharples, AP (2019) UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy. The Journal of Physiology. ISSN 0022-3751

Turner, DC, Seaborne, RA and Sharples, AP (2019) Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory. Scientific Reports. ISSN 2045-2322

Seaborne, RA, Strauss, JA, Cocks, MS, Shepherd, SO, O'Brien, TD, van Someren, KA, Bell, PG, Murgatroyd, C, Morton, JP, Stewart, CE, Mein, CA and Sharples, AP (2018) Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining. Scientific Data, 5. ISSN 2052-4463

Impey, SG, Hammond, KM, Naughton, R, Langan-Evans, C, Shepherd, SO, Sharples, AP, Cegielski, J, Smith, K, Jeromson, S, Hamilton, DL, Close, GL and Morton, JP (2018) Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability. International Journal of Sport Nutrition and Exercise Metabolism. ISSN 1526-484X

Seaborne, RA, Strauss, JA, Cocks, MS, Shepherd, SO, O'Brien, TD, van Someren, KA, Bell, PG, Murgatroyd, C, Morton, JP, Stewart, CE and Sharples, AP (2018) Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy. Scientific Reports, 8. ISSN 2045-2322

Dugdale, HF, Hughes, DC, Allan, R, Deane, CS, Coxon, CR, Morton, JP, Stewart, CE and Sharples, AP (2017) The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction. Molecular and Cellular Biochemistry. ISSN 1573-4919

Brown, AD, Close, GL, Sharples, AP and Stewart, CE (2017) Murine myoblast migration: influence of replicative ageing and nutrition. Biogerontology. ISSN 1389-5729

Fisher, A, Seaborne, RA, Hughes, TM, Gutteridge, A, Stewart, CE, Coulson, JM, Sharples, AP and Jarvis, JC (2017) Transcriptomic and Epigenetic Regulation of Disuse Atrophy and the Return to Activity in Skeletal Muscle. FASEB Journal, Epub A. ISSN 1530-6860

Allan, R, Sharples, AP, Close, GL, Drust, B, Shepherd, SO, Dutton, J, Morton, JP and Gregson, W (2017) Postexercise cold water immersion modulates skeletal muscle PGC-1 alpha mRNA expression in immersed and nonimmersed limbs: evidence of systemic regulation. Journal of Applied Physiology, 123 (2). pp. 451-459. ISSN 8750-7587

Kasper, AM, Turner, DC, Martin, NRW and Sharples, AP (2017) Mimicking exercise in three-dimensional bioengineered skeletal muscle to investigate cellular and molecular mechanisms of physiological adaptation. Journal of Cellular Physiology. ISSN 0021-9541

Saini, A, Sharples, AP, Al-Shanti, N and Stewart, CE (2016) Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Biogerontology (Epup A). ISSN 1573-6768

Hammond, KM, Impey, SG, Currell, K, Mitchell, N, Shepherd, SO, Jeromson, S, Hawley, JA, Close, GL, Hamilton, DL, Sharples, AP and Morton, JP (2016) Postexercise High-Fat Feeding Supresses p70S6K1 Activity in Human Skeletal Muscle. Medicine and Science in Sports and Exercise. ISSN 1530-0315

Impey, SG, Hammond, KM, Shepherd, SO, Sharples, AP, Stewart, CE, Limb, M, Smith, K, Philp, A, Jeromson, S, Hamilton, DL, Close, GL and Morton, JP (2016) Fuel for the work required: a practical approach to amalgamating train-low paradigms for endurance athletes. Physiological Reports, 4 (10). ISSN 2051-817X

Sharples, AP, Stewart, CE and Seaborne, RA (2016) Does skeletal muscle have an ‘epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise. Aging Cell. ISSN 1474-9726

Girven, M, Dugdale, HF, Owens, DJ, Hughes, DC, Stewart, CE and Sharples, AP (2016) L-glutamine improves skeletal muscle cell differentiation and prevents myotube atrophy after cytokine (TNF-α) stress via reduced p38 MAPK signal transduction. Journal of Cellular Physiology. ISSN 1097-4652

Owens, DJ, Sharples, AP, Polydorou, I, Alwan, N, Donovan, TD, Tang, J, Fraser, WD, Cooper, RG, Morton, JP, Stewart, CE and Close, GL (2015) A Systems Based Investigation into Vitamin D and Skeletal Muscle Repair, Regeneration and Hypertrophy. American Journal of Physiology Endocrinology and Metabolism, 309 (12). E1019-E1031. ISSN 0193-1849

Hughes, DH, Stewart, CE, Sculthorpe, N, Dugdale, HF, Yousefian, F, Lewis, MP and Sharples, AP (2015) Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors. Biogerontology, Epub A. pp. 1-21. ISSN 1573-6768

Sharples, AP, Polydorou, I, Hughes, DC, Owens, DJ, Hughes, TM and Stewart, CE (2015) Skeletal muscle cells possess a 'memory' of acute early life TNF-α exposure: role of epigenetic adaptation. Biogerontology. pp. 1-15. ISSN 1573-6768

Sharples, AP, Hughes, DC, Deane, CS, Saini, A, Selman, C and Stewart, CE (2015) Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell. pp. 1-13. ISSN 1474-9726

Deane, CD, Hughes, DC, Sculthorpe, N, Lewis, MP, Stewart, CE and Sharples, AP (2013) Impaired hypertrophy in myoblasts is improved with testosterone administration. Journal of Steroid Biochemistry and Molecular Biology, 138. pp. 152-161. ISSN 1879-1220

Sharples, AP, Player, DJ, Martin, NRW, Mudera, V, Stewart, CE and Lewis, MP (2012) Modelling in vivo skeletal muscle ageing in vitro using three-dimensional bioengineered constructs. AGING CELL, 11 (6). pp. 986-995. ISSN 1474-9718

Sharples, AP and Stewart, CE (2011) Myoblast models of skeletal muscle hypertrophy and atrophy. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 14 (3). pp. 230-236. ISSN 1363-1950

Book Section

Turner, DC, Kasper, AM, Seaborne, RA, Brown, AD, Close, GL, Murphy, MF, Stewart, CE, Martin, NRW and Sharples, AP (2018) Exercising Bioengineered Skeletal Muscle In Vitro: Biopsy to Bioreactor. In: Myogenesis: Methods and Protocols. Springer, New York, pp. 55-79. ISBN 9781493988969